Accelerated sequence divergence of conserved genomic elements in Drosophila melanogaster Export

@article{citeulike:2942379, abstract = {Recent genomic sequencing of 10 additional Drosophila genomes provides a rich resource for comparative genomics analyses aimed at understanding the similarities and differences between species and between Drosophila and mammals. Using a phylogenetic approach, we identified 64 genomic elements that have been highly conserved over most of the Drosophila tree, but that have experienced a recent burst of evolution along the Drosophila melanogaster lineage. Compared to similarly defined elements in humans, these regions of rapid lineage-specific evolution in Drosophila differ dramatically in location, mechanism of evolution, and functional properties of associated genes. Notably, the majority reside in protein coding regions and primarily result from rapid adaptive synonymous site evolution. In fact, adaptive evolution appears to be driving substitutions to unpreferred codons. Our analysis also highlights interesting noncoding genomic regions, such as regulatory regions in the gene gooseberry-neuro and a putative novel miRNA. 10.1101/gr.077131.108}, author = {Holloway, Alisha and Begun, David and Siepel, Adam and Pollard, Katherine}, citeulike-article-id = {2942379}, citeulike-linkout-0 = {http://dx.doi.org/10.1101/gr.077131.108}, citeulike-linkout-1 = {http://genome.cshlp.org/content/18/10/1592.abstract}, citeulike-linkout-2 = {http://genome.cshlp.org/content/18/10/1592.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/18583644}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=18583644}, day = {26}, doi = {10.1101/gr.077131.108}, journal = {Genome Res.}, keywords = {cns-ranking, coding}, month = {June}, pages = {gr.077131.108+}, posted-at = {2008-07-07 22:22:57}, priority = {2}, title = {Accelerated sequence divergence of conserved genomic elements in Drosophila melanogaster}, url = {http://dx.doi.org/10.1101/gr.077131.108}, year = {2008} }

TY - JOUR ID - citeulike:2942379 L3 - citeulike-article-id:2942379 N2 - Recent genomic sequencing of 10 additional Drosophila genomes provides a rich resource for comparative genomics analyses aimed at understanding the similarities and differences between species and between Drosophila and mammals. Using a phylogenetic approach, we identified 64 genomic elements that have been highly conserved over most of the Drosophila tree, but that have experienced a recent burst of evolution along the Drosophila melanogaster lineage. Compared to similarly defined elements in humans, these regions of rapid lineage-specific evolution in Drosophila differ dramatically in location, mechanism of evolution, and functional properties of associated genes. Notably, the majority reside in protein coding regions and primarily result from rapid adaptive synonymous site evolution. In fact, adaptive evolution appears to be driving substitutions to unpreferred codons. Our analysis also highlights interesting noncoding genomic regions, such as regulatory regions in the gene gooseberry-neuro and a putative novel miRNA. 10.1101/gr.077131.108 JF - Genome Res. TI - Accelerated sequence divergence of conserved genomic elements in Drosophila melanogaster SP - gr.077131.108 KW - cns-ranking KW - coding AU - Holloway, Alisha AU - Begun, David AU - Siepel, Adam AU - Pollard, Katherine PY - 2008/06/26/ UR - http://dx.doi.org/10.1101/gr.077131.108 ER -