The functional consequences of alternative promoter use in mammalian genomes Export

@article{citeulike:3150416, abstract = {We are beginning to appreciate the increasing complexity of mammalian gene structure. A phenomenon that adds an important dimension to this complexity is the use of alternative gene promoters that drive widespread cell type, tissue type or developmental gene regulation. Recent annotations of the human genome suggest that almost one half of the protein-coding genes contain alternative promoters, including those of many disease-associated genes. Aberrant use of one promoter over another has been found to be associated with various diseases, including cancer. Here we discuss the functional consequences of use and misuse of alternative promoters in normal and disease genomes and review the molecular mechanisms regulating alternative promoter use in mammalian genomes.}, address = {Human Cancer Genetics Program, Comprehensive Cancer Center, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA. ramana.davuluri@osumc.edu}, author = {Davuluri, R. and Suzuki, Y. and Sugano, S. and Plass, C. and Huang, T.}, citeulike-article-id = {3150416}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.tig.2008.01.008}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0168952508000590}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18329129}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18329129}, doi = {10.1016/j.tig.2008.01.008}, issn = {01689525}, journal = {Trends in Genetics}, keywords = {alternative\_splicing, gene\_regulation, promoter, tata, tissue\_specific}, month = {April}, number = {4}, pages = {167--177}, posted-at = {2009-10-29 15:35:42}, priority = {2}, title = {The functional consequences of alternative promoter use in mammalian genomes}, url = {http://dx.doi.org/10.1016/j.tig.2008.01.008}, volume = {24}, year = {2008} }

TY - JOUR ID - citeulike:3150416 L3 - citeulike-article-id:3150416 N2 - We are beginning to appreciate the increasing complexity of mammalian gene structure. A phenomenon that adds an important dimension to this complexity is the use of alternative gene promoters that drive widespread cell type, tissue type or developmental gene regulation. Recent annotations of the human genome suggest that almost one half of the protein-coding genes contain alternative promoters, including those of many disease-associated genes. Aberrant use of one promoter over another has been found to be associated with various diseases, including cancer. Here we discuss the functional consequences of use and misuse of alternative promoters in normal and disease genomes and review the molecular mechanisms regulating alternative promoter use in mammalian genomes. IS - 4 JF - Trends in Genetics SN - 01689525 AD - Human Cancer Genetics Program, Comprehensive Cancer Center, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA. ramana.davuluri@osumc.edu EP - 177 TI - The functional consequences of alternative promoter use in mammalian genomes VL - 24 SP - 167 KW - alternative_splicing KW - gene_regulation KW - promoter KW - tata KW - tissue_specific AU - Davuluri, R AU - Suzuki, Y AU - Sugano, S AU - Plass, C AU - Huang, T PY - 2008/04// UR - http://dx.doi.org/10.1016/j.tig.2008.01.008 ER -