Semen-Derived Amyloid Fibrils Drastically Enhance HIV Infection Export

@article{citeulike:2116273, abstract = {Summary Sexual intercourse is the major route of HIV transmission. To identify endogenous factors that affect the efficiency of sexual viral transmission, we screened a complex peptide/protein library derived from human semen. We show that naturally occurring fragments of the abundant semen marker prostatic acidic phosphatase (PAP) form amyloid fibrils. These fibrils, termed Semen-derived Enhancer of Virus Infection (SEVI), capture HIV virions and promote their attachment to target cells, thereby enhancing the infectious virus titer by several orders of magnitude. Physiological concentrations of SEVI amplified HIV infection of T cells, macrophages, ex vivo human tonsillar tissues, and transgenic rats in vivo, as well as trans-HIV infection of T cells by dendritic or epithelial cells. Amyloidogenic PAP fragments are abundant in seminal fluid and boost semen-mediated enhancement of HIV infection. Thus, they may play an important role in sexual transmission of HIV and could represent new targets for its prevention.}, author = {Munch, Jan and Rucker, Elke and Standker, Ludger and Adermann, Knut and Goffinet, Christine and Schindler, Michael and Wildum, Steffen and Chinnadurai, Raghavan and Rajan, Devi and Specht, Anke and Gimenez-Gallego, Guillermo and Sanchez, Pedro C. and Fowler, Douglas M. and Koulov, Atanas and Kelly, Jeffery W. and Mothes, Walther and Grivel, Jean-Charles and Margolis, Leonid and Keppler, Oliver T. and Forssmann, Wolf-Georg and Kirchhoff, Frank}, citeulike-article-id = {2116273}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.cell.2007.10.014}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18083097}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18083097}, citeulike-linkout-3 = {http://www.sciencedirect.com/science/article/B6WSN-4RBM53P-C/2/62ad2639cea33d4249f0af300aa44c4f}, day = {14}, doi = {10.1016/j.cell.2007.10.014}, journal = {Cell}, keywords = {entry, hiv}, month = {December}, number = {6}, pages = {1059--1071}, posted-at = {2007-12-14 16:43:08}, priority = {0}, title = {Semen-Derived Amyloid Fibrils Drastically Enhance HIV Infection}, url = {http://dx.doi.org/10.1016/j.cell.2007.10.014}, volume = {131}, year = {2007} }

TY - JOUR ID - citeulike:2116273 L3 - citeulike-article-id:2116273 N2 - Summary Sexual intercourse is the major route of HIV transmission. To identify endogenous factors that affect the efficiency of sexual viral transmission, we screened a complex peptide/protein library derived from human semen. We show that naturally occurring fragments of the abundant semen marker prostatic acidic phosphatase (PAP) form amyloid fibrils. These fibrils, termed Semen-derived Enhancer of Virus Infection (SEVI), capture HIV virions and promote their attachment to target cells, thereby enhancing the infectious virus titer by several orders of magnitude. Physiological concentrations of SEVI amplified HIV infection of T cells, macrophages, ex vivo human tonsillar tissues, and transgenic rats in vivo, as well as trans-HIV infection of T cells by dendritic or epithelial cells. Amyloidogenic PAP fragments are abundant in seminal fluid and boost semen-mediated enhancement of HIV infection. Thus, they may play an important role in sexual transmission of HIV and could represent new targets for its prevention. IS - 6 JF - Cell EP - 1071 TI - Semen-Derived Amyloid Fibrils Drastically Enhance HIV Infection VL - 131 SP - 1059 KW - entry KW - hiv AU - Munch, Jan AU - Rucker, Elke AU - Standker, Ludger AU - Adermann, Knut AU - Goffinet, Christine AU - Schindler, Michael AU - Wildum, Steffen AU - Chinnadurai, Raghavan AU - Rajan, Devi AU - Specht, Anke AU - Gimenez-Gallego, Guillermo AU - Sanchez, Pedro AU - Fowler, Douglas AU - Koulov, Atanas AU - Kelly, Jeffery AU - Mothes, Walther AU - Grivel, Jean-Charles AU - Margolis, Leonid AU - Keppler, Oliver AU - Forssmann, Wolf-Georg AU - Kirchhoff, Frank PY - 2007/12/14/ UR - http://dx.doi.org/10.1016/j.cell.2007.10.014 ER -