The autophagy machinery is required to initiate hepatitis C virus replication Export

@article{citeulike:5487168, abstract = {10.1073/pnas.0907344106 In addition to its cellular homeostasis function, autophagy is emerging as a central component of antimicrobial host defense against diverse infections. To counteract this mechanism, many pathogens have evolved to evade, subvert, or exploit autophagy. Here, we report that autophagy proteins (i.e., Beclin-1, Atg4B, Atg5, and Atg12) are proviral factors required for translation of incoming hepatitis C virus (HCV) RNA and, thereby, for initiation of HCV replication, but they are not required once infection is established. These results illustrate a previously unappreciated role for autophagy in the establishment of a viral infection and they suggest that different host factors regulate the translation of incoming viral genome and translation of progeny HCV RNA once replication is established.}, author = {Dreux, Marl\`{e}ne and Gastaminza, Pablo and Wieland, Stefan F. and Chisari, Francis V.}, citeulike-article-id = {5487168}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0907344106}, citeulike-linkout-1 = {http://www.pnas.org/content/106/33/14046.abstract}, citeulike-linkout-2 = {http://www.pnas.org/content/106/33/14046.full.pdf}, day = {18}, doi = {10.1073/pnas.0907344106}, journal = {Proceedings of the National Academy of Sciences}, keywords = {entry, flavivirus}, month = {August}, number = {33}, pages = {14046--14051}, posted-at = {2009-08-19 17:36:24}, priority = {2}, title = {The autophagy machinery is required to initiate hepatitis C virus replication}, url = {http://dx.doi.org/10.1073/pnas.0907344106}, volume = {106}, year = {2009} }

TY - JOUR ID - citeulike:5487168 L3 - citeulike-article-id:5487168 N2 - 10.1073/pnas.0907344106 In addition to its cellular homeostasis function, autophagy is emerging as a central component of antimicrobial host defense against diverse infections. To counteract this mechanism, many pathogens have evolved to evade, subvert, or exploit autophagy. Here, we report that autophagy proteins (i.e., Beclin-1, Atg4B, Atg5, and Atg12) are proviral factors required for translation of incoming hepatitis C virus (HCV) RNA and, thereby, for initiation of HCV replication, but they are not required once infection is established. These results illustrate a previously unappreciated role for autophagy in the establishment of a viral infection and they suggest that different host factors regulate the translation of incoming viral genome and translation of progeny HCV RNA once replication is established. IS - 33 JF - Proceedings of the National Academy of Sciences EP - 14051 TI - The autophagy machinery is required to initiate hepatitis C virus replication VL - 106 SP - 14046 KW - entry KW - flavivirus AU - Dreux, Marlène AU - Gastaminza, Pablo AU - Wieland, Stefan AU - Chisari, Francis PY - 2009/08/18/ UR - http://dx.doi.org/10.1073/pnas.0907344106 ER -