Breadth of Neutralizing Antibody Response to Human Immunodeficiency Virus Type 1 Is Affected by Factors Early in Infection but Does Not Influence Disease Progression Export

@article{citeulike:5776206, abstract = {The determinants of a broad neutralizing antibody (NAb) response and its effect on human immunodeficiency virus type 1 (HIV-1) disease progression are not well defined, partly because most prior studies of a broad NAb response were cross-sectional. We examined correlates of NAb response breadth among 70 HIV-infected, antiretroviral-naive Kenyan women from a longitudinal seroincident cohort. NAb response breadth was measured 5 years after infection against five subtype A viruses and one subtype B virus. Greater NAb response breadth was associated with a higher viral load set point and greater HIV-1 env diversity early in infection. However, greater NAb response breadth was not associated with a delayed time to a CD4+ T-cell count of <200, antiretroviral therapy, or death. Thus, a broad NAb response results from a high level of antigenic stimulation early in infection, which likely accounts for prior observations that greater NAb response breadth is associated with a higher viral load later in infection. 10.1128/JVI.01149-09}, author = {Piantadosi, Anne and Panteleeff, Dana and Blish, Catherine A. and Baeten, Jared M. and Jaoko, Walter and McClelland, R. Scott and Overbaugh, Julie}, citeulike-article-id = {5776206}, citeulike-linkout-0 = {http://dx.doi.org/10.1128/JVI.01149-09}, citeulike-linkout-1 = {http://jvi.asm.org/cgi/content/abstract/83/19/10269}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19640996}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19640996}, day = {1}, doi = {10.1128/JVI.01149-09}, journal = {J. Virol.}, keywords = {hiv, neutralization, pathogenesis}, month = {October}, number = {19}, pages = {10269--10274}, posted-at = {2009-09-11 16:50:39}, priority = {2}, title = {Breadth of Neutralizing Antibody Response to Human Immunodeficiency Virus Type 1 Is Affected by Factors Early in Infection but Does Not Influence Disease Progression}, url = {http://dx.doi.org/10.1128/JVI.01149-09}, volume = {83}, year = {2009} }

TY - JOUR ID - citeulike:5776206 L3 - citeulike-article-id:5776206 N2 - The determinants of a broad neutralizing antibody (NAb) response and its effect on human immunodeficiency virus type 1 (HIV-1) disease progression are not well defined, partly because most prior studies of a broad NAb response were cross-sectional. We examined correlates of NAb response breadth among 70 HIV-infected, antiretroviral-naive Kenyan women from a longitudinal seroincident cohort. NAb response breadth was measured 5 years after infection against five subtype A viruses and one subtype B virus. Greater NAb response breadth was associated with a higher viral load set point and greater HIV-1 env diversity early in infection. However, greater NAb response breadth was not associated with a delayed time to a CD4+ T-cell count of <200, antiretroviral therapy, or death. Thus, a broad NAb response results from a high level of antigenic stimulation early in infection, which likely accounts for prior observations that greater NAb response breadth is associated with a higher viral load later in infection. 10.1128/JVI.01149-09 IS - 19 JF - J. Virol. EP - 10274 TI - Breadth of Neutralizing Antibody Response to Human Immunodeficiency Virus Type 1 Is Affected by Factors Early in Infection but Does Not Influence Disease Progression VL - 83 SP - 10269 KW - hiv KW - neutralization KW - pathogenesis AU - Piantadosi, Anne AU - Panteleeff, Dana AU - Blish, Catherine AU - Baeten, Jared AU - Jaoko, Walter AU - McClelland, Scott AU - Overbaugh, Julie PY - 2009/10/01/ UR - http://dx.doi.org/10.1128/JVI.01149-09 ER -