Did homeodomain proteins duplicate before the origin of angiosperms, fungi, and metazoa? Export

@article{Bharathan1997, abstract = {Homeodomain proteins are transcription factors that play a critical role in early development in eukaryotes. These proteins previously have been classified into numerous subgroups whose phylogenetic relationships are unclear. Our phylogenetic analysis of representative eukaryotic sequences suggests that there are two major groups of homeodomain proteins, each containing sequences from angiosperms, metazoa, and fungi. This result, based on parsimony and neighbor-joining analyses of primary amino acid sequences, was supported by two additional features of the proteins. The two protein groups are distinguished by an insertion/deletion in the homeodomain, between helices I and II. In addition, an amphipathic alpha-helical secondary structure in the region N terminal of the homeodomain is shared by angiosperm and metazoan sequences in one group. These results support the hypothesis that there was at least one duplication of homeobox genes before the origin of angiosperms, fungi, and metazoa. This duplication, in turn, suggests that these proteins had diverse functions early in the evolution of eukaryotes. The shared secondary structure in angiosperm and metazoan sequences points to an ancient conserved functional domain.}, author = {Bharathan, G. and Janssen, B. J. and Kellogg, E. A. and Sinha, N.}, citeulike-article-id = {757367}, journal = {Proc. Natl. Acad. Sci. U. S. A.}, keywords = {9391098, acid, amino, angiosperms, animals, bibtex-import, comparative, data, evolution, family, fungi, genes, genetic, govt, homeobox, homeodomain, homology, humans, models, molecular, multigene, non-phs, non-us, phylogeny, protein, proteins, research, secondary, sequence, structure, study, support, us}, month = {Dec}, number = {25}, pages = {13749--53}, pdf = {Bharathan1997.pdf}, posted-at = {2006-07-13 16:23:13}, priority = {2}, title = {Did homeodomain proteins duplicate before the origin of angiosperms, fungi, and metazoa?}, volume = {94}, year = {1997} }

TY - JOUR ID - Bharathan1997 L3 - citeulike-article-id:757367 N2 - Homeodomain proteins are transcription factors that play a critical role in early development in eukaryotes. These proteins previously have been classified into numerous subgroups whose phylogenetic relationships are unclear. Our phylogenetic analysis of representative eukaryotic sequences suggests that there are two major groups of homeodomain proteins, each containing sequences from angiosperms, metazoa, and fungi. This result, based on parsimony and neighbor-joining analyses of primary amino acid sequences, was supported by two additional features of the proteins. The two protein groups are distinguished by an insertion/deletion in the homeodomain, between helices I and II. In addition, an amphipathic alpha-helical secondary structure in the region N terminal of the homeodomain is shared by angiosperm and metazoan sequences in one group. These results support the hypothesis that there was at least one duplication of homeobox genes before the origin of angiosperms, fungi, and metazoa. This duplication, in turn, suggests that these proteins had diverse functions early in the evolution of eukaryotes. The shared secondary structure in angiosperm and metazoan sequences points to an ancient conserved functional domain. IS - 25 JF - Proc. Natl. Acad. Sci. U. S. A. EP - 53 TI - Did homeodomain proteins duplicate before the origin of angiosperms, fungi, and metazoa? VL - 94 SP - 13749 KW - 9391098 KW - acid KW - amino KW - angiosperms KW - animals KW - bibtex-import KW - comparative KW - data KW - evolution KW - family KW - fungi KW - genes KW - genetic KW - govt KW - homeobox KW - homeodomain KW - homology KW - humans KW - models KW - molecular KW - multigene KW - non-phs KW - non-us KW - phylogeny KW - protein KW - proteins KW - research KW - secondary KW - sequence KW - structure KW - study KW - support KW - us AU - Bharathan, G AU - Janssen, BJ AU - Kellogg, EA AU - Sinha, N PY - 1997/Dec// ER -