Transgenic mice with a reduced core body temperature have an increased life span.

@article{citeulike:2594154, abstract = {Reduction of core body temperature has been proposed to contribute to the increased life span and the antiaging effects conferred by calorie restriction (CR). Validation of this hypothesis has been difficult in homeotherms, primarily due to a lack of experimental models. We report that transgenic mice engineered to overexpress the uncoupling protein 2 in hypocretin neurons (Hcrt-UCP2) have elevated hypothalamic temperature. The effects of local temperature elevation on the central thermostat resulted in a 0.3 degrees to 0.5 degrees C reduction of the core body temperature. Fed ad libitum, Hcrt-UCP2 transgenic mice had the same caloric intake as their wild-type littermates but had increased energy efficiency and a greater median life span (12\% increase in males; 20\% increase in females). Thus, modest, sustained reduction of core body temperature prolonged life span independent of altered diet or CR.}, address = {Harold L. Dorris Neurological Research Center, Scripps Research Institute, La Jolla, CA 92037, USA. bconti@scripps.edu}, author = {Conti, B. and Sanchez-Alavez, M. and Winsky-Sommerer, R. and Morale, M. C. and Lucero, J. and Brownell, S. and Fabre, V. and Huitron-Resendiz, S. and Henriksen, S. and Zorrilla, E. P. and de Lecea, L. and Bartfai, T. }, citeulike-article-id = {2594154}, doi = {10.1126/science.1132191}, issn = {1095-9203}, journal = {Science}, month = {November}, number = {5800}, pages = {825--828}, posted-at = {2008-03-26 13:17:40}, priority = {2}, title = {Transgenic mice with a reduced core body temperature have an increased life span.}, url = {http://dx.doi.org/10.1126/science.1132191}, volume = {314}, year = {2006} }

TY - JOUR ID - citeulike:2594154 L3 - citeulike-article-id:2594154 TI - Transgenic mice with a reduced core body temperature have an increased life span. JF - Science VL - 314 IS - 5800 SP - 825 EP - 828 AD - Harold L. Dorris Neurological Research Center, Scripps Research Institute, La Jolla, CA 92037, USA. bconti@scripps.edu SN - 1095-9203 N2 - Reduction of core body temperature has been proposed to contribute to the increased life span and the antiaging effects conferred by calorie restriction (CR). Validation of this hypothesis has been difficult in homeotherms, primarily due to a lack of experimental models. We report that transgenic mice engineered to overexpress the uncoupling protein 2 in hypocretin neurons (Hcrt-UCP2) have elevated hypothalamic temperature. The effects of local temperature elevation on the central thermostat resulted in a 0.3 degrees to 0.5 degrees C reduction of the core body temperature. Fed ad libitum, Hcrt-UCP2 transgenic mice had the same caloric intake as their wild-type littermates but had increased energy efficiency and a greater median life span (12% increase in males; 20% increase in females). Thus, modest, sustained reduction of core body temperature prolonged life span independent of altered diet or CR. AU - Conti, B AU - Sanchez-Alavez, M AU - Winsky-Sommerer, R AU - Morale, MC AU - Lucero, J AU - Brownell, S AU - Fabre, V AU - Huitron-Resendiz, S AU - Henriksen, S AU - Zorrilla, EP AU - de Lecea, L AU - Bartfai, T PY - 2006/11/03/ UR - http://dx.doi.org/10.1126/science.1132191 ER -