Genome sequence of Aedes aegypti, a major arbovirus vector. Export

@article{citeulike:1324980, abstract = {We present a draft sequence of the genome of Aedes aegypti, the primary vector for yellow fever and dengue fever, which at approximately 1376 million base pairs is about 5 times the size of the genome of the malaria vector Anopheles gambiae. Nearly 50\% of the Ae. aegypti genome consists of transposable elements. These contribute to a factor of approximately 4 to 6 increase in average gene length and in sizes of intergenic regions relative to An. gambiae and Drosophila melanogaster. Nonetheless, chromosomal synteny is generally maintained among all three insects, although conservation of orthologous gene order is higher (by a factor of approximately 2) between the mosquito species than between either of them and the fruit fly. An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to An. gambiae suggests that members of these protein families underpin some of the biological differences between the two mosquito species.}, address = {The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.}, author = {Nene, Vishvanath and Wortman, Jennifer R. and Lawson, Daniel and Haas, Brian and Kodira, Chinnappa and Tu, Zhijian Jake J. and Loftus, Brendan and Xi, Zhiyong and Megy, Karyn and Grabherr, Manfred and Ren, Quinghu and Zdobnov, Evgeny M. and Lobo, Neil F. and Campbell, Kathryn S. and Brown, Susan E. and Bonaldo, Maria F. and Zhu, Jingsong and Sinkins, Steven P. and Hogenkamp, David G. and Amedeo, Paolo and Arensburger, Peter and Atkinson, Peter W. and Bidwell, Shelby and Biedler, Jim and Birney, Ewan and Bruggner, Robert V. and Costas, Javier and Coy, Monique R. and Crabtree, Jonathan and Crawford, Matt and Debruyn, Becky and Decaprio, David and Eiglmeier, Karin and Eisenstadt, Eric and El-Dorry, Hamza and Gelbart, William M. and Gomes, Suely L. and Hammond, Martin and Hannick, Linda I. and Hogan, James R. and Holmes, Michael H. and Jaffe, David and Johnston, J. Spencer and Kennedy, Ryan C. and Koo, Hean and Kravitz, Saul and Kriventseva, Evgenia V. and Kulp, David and Labutti, Kurt and Lee, Eduardo and Li, Song and Lovin, Diane D. and Mao, Chunhong and Mauceli, Evan and Menck, Carlos F. and Miller, Jason R. and Montgomery, Philip and Mori, Akio and Nascimento, Ana L. and Naveira, Horacio F. and Nusbaum, Chad and O'leary, Sin\'{e}ad and Orvis, Joshua and Pertea, Mihaela and Quesneville, Hadi and Reidenbach, Kyanne R. and Rogers, Yu-Hui H. and Roth, Charles W. and Schneider, Jennifer R. and Schatz, Michael and Shumway, Martin and Stanke, Mario and Stinson, Eric O. and Tubio, Jose M. and Vanzee, Janice P. and Verjovski-Almeida, Sergio and Werner, Doreen and White, Owen and Wyder, Stefan and Zeng, Qiandong and Zhao, Qi and Zhao, Yongmei and Hill, Catherine A. and Raikhel, Alexander S. and Soares, Marcelo B. and Knudson, Dennis L. and Lee, Norman H. and Galagan, James and Salzberg, Steven L. and Paulsen, Ian T. and Dimopoulos, George and Collins, Frank H. and Birren, Bruce and Fraser-Liggett, Claire M. and Severson, David W.}, citeulike-article-id = {1324980}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1138878}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/316/5832/1718}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17510324}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17510324}, day = {22}, doi = {10.1126/science.1138878}, issn = {1095-9203}, journal = {Science (New York, N.Y.)}, keywords = {aedes, genome\_paper, mosquito}, month = {June}, number = {5832}, pages = {1718--1723}, posted-at = {2007-12-16 01:01:12}, priority = {2}, title = {Genome sequence of Aedes aegypti, a major arbovirus vector.}, url = {http://dx.doi.org/10.1126/science.1138878}, volume = {316}, year = {2007} }

TY - JOUR ID - citeulike:1324980 L3 - citeulike-article-id:1324980 N2 - We present a draft sequence of the genome of Aedes aegypti, the primary vector for yellow fever and dengue fever, which at approximately 1376 million base pairs is about 5 times the size of the genome of the malaria vector Anopheles gambiae. Nearly 50% of the Ae. aegypti genome consists of transposable elements. These contribute to a factor of approximately 4 to 6 increase in average gene length and in sizes of intergenic regions relative to An. gambiae and Drosophila melanogaster. Nonetheless, chromosomal synteny is generally maintained among all three insects, although conservation of orthologous gene order is higher (by a factor of approximately 2) between the mosquito species than between either of them and the fruit fly. An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to An. gambiae suggests that members of these protein families underpin some of the biological differences between the two mosquito species. IS - 5832 JF - Science (New York, N.Y.) SN - 1095-9203 AD - The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA. EP - 1723 TI - Genome sequence of Aedes aegypti, a major arbovirus vector. VL - 316 SP - 1718 KW - aedes KW - genome_paper KW - mosquito AU - Nene, Vishvanath AU - Wortman, Jennifer AU - Lawson, Daniel AU - Haas, Brian AU - Kodira, Chinnappa AU - Tu, Zhijian Jake AU - Loftus, Brendan AU - Xi, Zhiyong AU - Megy, Karyn AU - Grabherr, Manfred AU - Ren, Quinghu AU - Zdobnov, Evgeny AU - Lobo, Neil AU - Campbell, Kathryn AU - Brown, Susan AU - Bonaldo, Maria AU - Zhu, Jingsong AU - Sinkins, Steven AU - Hogenkamp, David AU - Amedeo, Paolo AU - Arensburger, Peter AU - Atkinson, Peter AU - Bidwell, Shelby AU - Biedler, Jim AU - Birney, Ewan AU - Bruggner, Robert AU - Costas, Javier AU - Coy, Monique AU - Crabtree, Jonathan AU - Crawford, Matt AU - Debruyn, Becky AU - Decaprio, David AU - Eiglmeier, Karin AU - Eisenstadt, Eric AU - El-Dorry, Hamza AU - Gelbart, William AU - Gomes, Suely AU - Hammond, Martin AU - Hannick, Linda AU - Hogan, James AU - Holmes, Michael AU - Jaffe, David AU - Johnston, Spencer AU - Kennedy, Ryan AU - Koo, Hean AU - Kravitz, Saul AU - Kriventseva, Evgenia AU - Kulp, David AU - Labutti, Kurt AU - Lee, Eduardo AU - Li, Song AU - Lovin, Diane AU - Mao, Chunhong AU - Mauceli, Evan AU - Menck, Carlos AU - Miller, Jason AU - Montgomery, Philip AU - Mori, Akio AU - Nascimento, Ana AU - Naveira, Horacio AU - Nusbaum, Chad AU - O'leary, Sinéad AU - Orvis, Joshua AU - Pertea, Mihaela AU - Quesneville, Hadi AU - Reidenbach, Kyanne AU - Rogers, Yu-Hui AU - Roth, Charles AU - Schneider, Jennifer AU - Schatz, Michael AU - Shumway, Martin AU - Stanke, Mario AU - Stinson, Eric AU - Tubio, Jose AU - Vanzee, Janice AU - Verjovski-Almeida, Sergio AU - Werner, Doreen AU - White, Owen AU - Wyder, Stefan AU - Zeng, Qiandong AU - Zhao, Qi AU - Zhao, Yongmei AU - Hill, Catherine AU - Raikhel, Alexander AU - Soares, Marcelo AU - Knudson, Dennis AU - Lee, Norman AU - Galagan, James AU - Salzberg, Steven AU - Paulsen, Ian AU - Dimopoulos, George AU - Collins, Frank AU - Birren, Bruce AU - Fraser-Liggett, Claire AU - Severson, David PY - 2007/06/22/ UR - http://dx.doi.org/10.1126/science.1138878 ER -