Escape from adaptive conflict after duplication in an anthocyanin pathway gene Export

@article{citeulike:2932567, abstract = {Gene duplications have been recognized as an important source of evolutionary innovation and adaptation since at least Haldane1, and their varying fates may partly explain the vast disparity in observed genome sizes2. The expected fates of most gene duplications involve primarily non-adaptive substitutions leading to either non-functionalization of one duplicate copy or subfunctionalization3, neither of which yields novel function. A significant evolutionary problem is thus elucidating the mechanisms of adaptive evolutionary change leading to evolutionary novelty. Currently, the most widely recognized adaptive process involving gene duplication is neo-functionalization (NEO-F), in which one copy undergoes directional selection to perform a novel function after duplication4. An alternative, but understudied, adaptive fate that has been proposed is escape from adaptive conflict (EAC), in which a single-copy gene is selected to perform a novel function while maintaining its ancestral function5, 6. This gene is constrained from improving either novel or ancestral function because of detrimental pleiotropic effects on the other function. After duplication, one copy is free to improve novel function, whereas the other is selected to improve ancestral function. Here we first present two criteria that can be used to distinguish NEO-F from EAC. Using both tests for positive selection and assays of enzyme function, we then demonstrate that adaptive evolutionary change in a duplicated gene of the anthocyanin biosynthetic pathway in morning glories (Ipomoea) is best interpreted as EAC. Finally, we argue that this phenomenon likely occurs more often than has been previously believed and may thus represent an important mechanism in generating evolutionary novelty.}, author = {Des Marais, David L. and Rausher, Mark D.}, booktitle = {Nature}, citeulike-article-id = {2932567}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature07092}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nature07092}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18594508}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18594508}, day = {25}, doi = {10.1038/nature07092}, issn = {0028-0836}, journal = {Nature}, keywords = {anthocyanin, duplication, gene, plants}, month = {June}, number = {7205}, pages = {762--765}, posted-at = {2008-07-07 03:32:20}, priority = {2}, publisher = {Nature Publishing Group}, title = {Escape from adaptive conflict after duplication in an anthocyanin pathway gene}, url = {http://dx.doi.org/10.1038/nature07092}, volume = {454}, year = {2008} }

TY - JOUR ID - citeulike:2932567 L3 - citeulike-article-id:2932567 N2 - Gene duplications have been recognized as an important source of evolutionary innovation and adaptation since at least Haldane1, and their varying fates may partly explain the vast disparity in observed genome sizes2. The expected fates of most gene duplications involve primarily non-adaptive substitutions leading to either non-functionalization of one duplicate copy or subfunctionalization3, neither of which yields novel function. A significant evolutionary problem is thus elucidating the mechanisms of adaptive evolutionary change leading to evolutionary novelty. Currently, the most widely recognized adaptive process involving gene duplication is neo-functionalization (NEO-F), in which one copy undergoes directional selection to perform a novel function after duplication4. An alternative, but understudied, adaptive fate that has been proposed is escape from adaptive conflict (EAC), in which a single-copy gene is selected to perform a novel function while maintaining its ancestral function5, 6. This gene is constrained from improving either novel or ancestral function because of detrimental pleiotropic effects on the other function. After duplication, one copy is free to improve novel function, whereas the other is selected to improve ancestral function. Here we first present two criteria that can be used to distinguish NEO-F from EAC. Using both tests for positive selection and assays of enzyme function, we then demonstrate that adaptive evolutionary change in a duplicated gene of the anthocyanin biosynthetic pathway in morning glories (Ipomoea) is best interpreted as EAC. Finally, we argue that this phenomenon likely occurs more often than has been previously believed and may thus represent an important mechanism in generating evolutionary novelty. IS - 7205 JF - Nature SN - 0028-0836 EP - 765 TI - Escape from adaptive conflict after duplication in an anthocyanin pathway gene PB - Nature Publishing Group VL - 454 T2 - Nature SP - 762 KW - anthocyanin KW - duplication KW - gene KW - plants AU - Des Marais, David AU - Rausher, Mark PY - 2008/06/25/ UR - http://dx.doi.org/10.1038/nature07092 ER -