Changes in allele-specific association of histone modifications at the imprinting control regions during mouse preimplantation development. Export

@article{citeulike:5838534, abstract = {Allele-specific association of histone modification is observed at the regulatory region of imprinted genes and has been suggested to work as an epigenetic marker for monoallelic gene expression, along with the allelic CpG methylation of DNA. Although the parent-origin-specific epigenetic status in imprinted genes is thought to be established during preimplantation development, little is known about the allelic specificity of histone modifications during this period because of the limited volume of material available for analysis. In this study, we first revealed the allelic enrichment of histone modifications and variant histones at the imprinting control regions (ICRs) of four-cell to blastocyst stage preimplantation embryos by using carrier chromatin immunoprecipitation and sequence polymorphism analysis of immunoprecipitated DNA. We found relative enrichment of histone H3 lysine 9 dimethylation at the imprinted alleles of ICRs and obtained the results suggesting that histone modifications at ICRs are established during a late preimplantation stage. genesis, 00:1-6, 2009. (c) 2009 Wiley-Liss, Inc.}, author = {Kim, Jin-Moon M. and Ogura, Atsuo}, citeulike-article-id = {5838534}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/dvg.20541}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19530139}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19530139}, day = {15}, doi = {10.1002/dvg.20541}, issn = {1526-968X}, journal = {Genesis (New York, N.Y. : 2000)}, keywords = {cerebelum, cpg, dmr, dna-methylation, h3k4me3, h3k9me3, heart, icr, imprint, imprinting, methylation, sdmr, sperm}, month = {June}, posted-at = {2009-09-24 23:53:06}, priority = {3}, title = {Changes in allele-specific association of histone modifications at the imprinting control regions during mouse preimplantation development.}, url = {http://dx.doi.org/10.1002/dvg.20541}, year = {2009} }

TY - JOUR ID - citeulike:5838534 L3 - citeulike-article-id:5838534 N2 - Allele-specific association of histone modification is observed at the regulatory region of imprinted genes and has been suggested to work as an epigenetic marker for monoallelic gene expression, along with the allelic CpG methylation of DNA. Although the parent-origin-specific epigenetic status in imprinted genes is thought to be established during preimplantation development, little is known about the allelic specificity of histone modifications during this period because of the limited volume of material available for analysis. In this study, we first revealed the allelic enrichment of histone modifications and variant histones at the imprinting control regions (ICRs) of four-cell to blastocyst stage preimplantation embryos by using carrier chromatin immunoprecipitation and sequence polymorphism analysis of immunoprecipitated DNA. We found relative enrichment of histone H3 lysine 9 dimethylation at the imprinted alleles of ICRs and obtained the results suggesting that histone modifications at ICRs are established during a late preimplantation stage. genesis, 00:1-6, 2009. (c) 2009 Wiley-Liss, Inc. JF - Genesis (New York, N.Y. : 2000) SN - 1526-968X TI - Changes in allele-specific association of histone modifications at the imprinting control regions during mouse preimplantation development. KW - cerebelum KW - cpg KW - dmr KW - dna-methylation KW - h3k4me3 KW - h3k9me3 KW - heart KW - icr KW - imprint KW - imprinting KW - methylation KW - sdmr KW - sperm AU - Kim, Jin-Moon AU - Ogura, Atsuo PY - 2009/06/15/ UR - http://dx.doi.org/10.1002/dvg.20541 ER -