Cocaine exposure during adolescence affects anxiety in adult mice. Export

@article{citeulike:1586108, abstract = {Psychostimulant drugs such as cocaine have profound and long-lasting neurobiological effects, which may affect anxiety or social behaviors. These actions could be greater when cocaine is administered during a developmental period such as adolescence. The present work attempts to further clarify the long-lasting effects of cocaine administration on mice, examining three major variables: age; pattern of drug administration; and housing conditions. Adolescent (postnatal day 26) or early adult mice (postnatal day 46) were exposed to a daily or binge cocaine administration and 15 days later their behavior was evaluated, the mice being housed either in isolation or in groups during this stage. After a period free of drug, the behaviors evaluated were: spontaneous and cocaine-induced motor activity; anxiety, using the elevated plus maze; the social profile, assessed in a social interaction test. Daily cocaine administration increased avoidance and flee in isolated adolescent-treated mice and decreased social contacts in those which were grouped. On the other hand, the binge pattern modified the anxiety of the grouped adolescent-treated mice evidenced by the increase in time spent on the open arms of the plus maze. An increase in spontaneous and cocaine-induced motor activity was shown in animals after a daily pre-treatment. The results are discussed in terms of presenting cocaine-induced behavioral changes within a specific temporal window and depending on the three variables studied.}, address = {Unidad de Investigaci\'{o}n Psicobiolog\'{\i}a de las Drogodependencias, Departamento de Psicobiolog\'{\i}a, Facultad de Psicolog\'{\i}a, Universitat de Valencia, Avda. Blasco Ib\'{a}\~{n}ez 21, 46010 Valencia, Spain.}, author = {Estelles, J. and Lluch, J. and Rodr\'{\i}guez-Arias, M. and Aguilar, M. A. and Mi\~{n}arro, J.}, citeulike-article-id = {1586108}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.brainresbull.2006.10.008}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17208657}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17208657}, day = {9}, doi = {10.1016/j.brainresbull.2006.10.008}, issn = {0361-9230}, journal = {Brain Res Bull}, keywords = {adolescence, anxiety, cocaine, epm}, month = {January}, number = {4}, pages = {393--403}, posted-at = {2007-08-23 15:52:29}, priority = {0}, title = {Cocaine exposure during adolescence affects anxiety in adult mice.}, url = {http://dx.doi.org/10.1016/j.brainresbull.2006.10.008}, volume = {71}, year = {2007} }

TY - JOUR ID - citeulike:1586108 L3 - citeulike-article-id:1586108 N2 - Psychostimulant drugs such as cocaine have profound and long-lasting neurobiological effects, which may affect anxiety or social behaviors. These actions could be greater when cocaine is administered during a developmental period such as adolescence. The present work attempts to further clarify the long-lasting effects of cocaine administration on mice, examining three major variables: age; pattern of drug administration; and housing conditions. Adolescent (postnatal day 26) or early adult mice (postnatal day 46) were exposed to a daily or binge cocaine administration and 15 days later their behavior was evaluated, the mice being housed either in isolation or in groups during this stage. After a period free of drug, the behaviors evaluated were: spontaneous and cocaine-induced motor activity; anxiety, using the elevated plus maze; the social profile, assessed in a social interaction test. Daily cocaine administration increased avoidance and flee in isolated adolescent-treated mice and decreased social contacts in those which were grouped. On the other hand, the binge pattern modified the anxiety of the grouped adolescent-treated mice evidenced by the increase in time spent on the open arms of the plus maze. An increase in spontaneous and cocaine-induced motor activity was shown in animals after a daily pre-treatment. The results are discussed in terms of presenting cocaine-induced behavioral changes within a specific temporal window and depending on the three variables studied. IS - 4 JF - Brain Res Bull SN - 0361-9230 AD - Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiología, Facultad de Psicología, Universitat de Valencia, Avda. Blasco Ibáñez 21, 46010 Valencia, Spain. EP - 403 TI - Cocaine exposure during adolescence affects anxiety in adult mice. VL - 71 SP - 393 KW - adolescence KW - anxiety KW - cocaine KW - epm AU - Estelles, J AU - Lluch, J AU - Rodríguez-Arias, M AU - Aguilar, MA AU - Miñarro, J PY - 2007/01/09/ UR - http://dx.doi.org/10.1016/j.brainresbull.2006.10.008 ER -