Expression of long-term depression underlies visual recognition memory.

@article{citeulike:2758027, abstract = {The modifications occurring in the brain during learning and memory are still poorly understood but may involve long-lasting changes in synaptic transmission (synaptic plasticity). In perirhinal cortex, a lasting decrement in neuronal responsiveness is associated with visual familiarity discrimination, leading to the hypothesis that long-term depression (LTD)-like synaptic plasticity may underlie recognition memory. LTD relies on internalization of AMPA receptors (AMPARs) through interaction between their GluR2 subunits and AP2, the clathrin adaptor protein required for endocytosis. We demonstrate that a peptide that blocks interactions between GluR2 and AP2 blocks LTD in perirhinal cortex in vitro. Viral transduction of this peptide in perirhinal cortex produced striking deficits in visual recognition memory. Furthermore, there was a deficit of LTD in perirhinal cortex slices from virally transduced, recognition memory-deficient animals. These results suggest that internalization of AMPA receptors, a process critical for the expression of LTD in perirhinal cortex, underlies visual recognition memory.}, address = {MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, UK.}, author = {Griffiths, S. and Scott, H. and Glover, C. and Bienemann, A. and Ghorbel, M. T. and Uney, J. and Brown, M. W. and Warburton, E. C. and Bashir, Z. I. }, citeulike-article-id = {2758027}, doi = {http://dx.doi.org/10.1016/j.neuron.2008.02.022}, issn = {1097-4199}, journal = {Neuron}, keywords = {kristina, recognition, shiva}, month = {April}, number = {2}, pages = {186--194}, posted-at = {2008-05-05 15:20:40}, priority = {2}, title = {Expression of long-term depression underlies visual recognition memory.}, url = {http://dx.doi.org/10.1016/j.neuron.2008.02.022}, volume = {58}, year = {2008} }

TY - JOUR ID - citeulike:2758027 L3 - citeulike-article-id:2758027 TI - Expression of long-term depression underlies visual recognition memory. JF - Neuron VL - 58 IS - 2 SP - 186 EP - 194 AD - MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, UK. SN - 1097-4199 N2 - The modifications occurring in the brain during learning and memory are still poorly understood but may involve long-lasting changes in synaptic transmission (synaptic plasticity). In perirhinal cortex, a lasting decrement in neuronal responsiveness is associated with visual familiarity discrimination, leading to the hypothesis that long-term depression (LTD)-like synaptic plasticity may underlie recognition memory. LTD relies on internalization of AMPA receptors (AMPARs) through interaction between their GluR2 subunits and AP2, the clathrin adaptor protein required for endocytosis. We demonstrate that a peptide that blocks interactions between GluR2 and AP2 blocks LTD in perirhinal cortex in vitro. Viral transduction of this peptide in perirhinal cortex produced striking deficits in visual recognition memory. Furthermore, there was a deficit of LTD in perirhinal cortex slices from virally transduced, recognition memory-deficient animals. These results suggest that internalization of AMPA receptors, a process critical for the expression of LTD in perirhinal cortex, underlies visual recognition memory. KW - kristina KW - recognition KW - shiva AU - Griffiths, S AU - Scott, H AU - Glover, C AU - Bienemann, A AU - Ghorbel, MT AU - Uney, J AU - Brown, MW AU - Warburton, EC AU - Bashir, ZI PY - 2008/04/24/ UR - http://dx.doi.org/10.1016/j.neuron.2008.02.022 ER -