Transcranial direct current stimulation improves recognition memory in Alzheimer disease.

@article{citeulike:2879573, abstract = {OBJECTIVE: To evaluate the cognitive effect of transcranial direct current stimulation (tDCS) over the temporoparietal areas in patients with Alzheimer disease (AD). METHODS: In 10 patients with probable AD, we delivered anodal tDCS (AtDCS), cathodal tDCS (CtDCS), and sham tDCS (StDCS) over the temporoparietal areas in three sessions. In each session recognition memory and visual attention were tested at baseline (prestimulation) and 30 minutes after tDCS ended (poststimulation). RESULTS: After AtDCS, accuracy of the word recognition memory task increased (prestimulation: 15.5 +/- 0.9, poststimulation: 17.9 +/- 0.8, p = 0.0068) whereas after CtDCS it decreased (15.8 +/- 0.6 vs 13.2 +/- 0.9, p = 0.011) and after StDCS it remained unchanged (16.3 +/- 0.7 vs 16.0 +/- 1.0, p = 0.75). tDCS left the visual attention-reaction times unchanged. CONCLUSION: Transcranial direct current stimulation (tDCS) delivered over the temporoparietal areas can specifically affect a recognition memory performance in patients with Alzheimer disease (AD). Because tDCS is simple, safe and inexpensive, our finding prompts studies using repeated tDCS, in conjunction with other therapeutic interventions for treating patients with AD.}, address = {From the Department of Neurological Sciences, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Italy.}, author = {Ferrucci, R and Mameli, F and Guidi, I and Mrakic-Sposta, S and Vergari, M and Marceglia, S and Cogiamanian, F and Barbieri, S and Scarpini, E and Priori, A }, citeulike-article-id = {2879573}, doi = {10.1212/01.wnl.0000317060.43722.a3}, issn = {1526-632X}, journal = {Neurology}, keywords = {kristina, memory, nichola}, month = {June}, posted-at = {2008-06-10 14:43:13}, priority = {2}, title = {Transcranial direct current stimulation improves recognition memory in Alzheimer disease.}, url = {http://dx.doi.org/10.1212/01.wnl.0000317060.43722.a3}, year = {2008} }

TY - JOUR ID - citeulike:2879573 L3 - citeulike-article-id:2879573 TI - Transcranial direct current stimulation improves recognition memory in Alzheimer disease. JF - Neurology AD - From the Department of Neurological Sciences, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Italy. SN - 1526-632X N2 - OBJECTIVE: To evaluate the cognitive effect of transcranial direct current stimulation (tDCS) over the temporoparietal areas in patients with Alzheimer disease (AD). METHODS: In 10 patients with probable AD, we delivered anodal tDCS (AtDCS), cathodal tDCS (CtDCS), and sham tDCS (StDCS) over the temporoparietal areas in three sessions. In each session recognition memory and visual attention were tested at baseline (prestimulation) and 30 minutes after tDCS ended (poststimulation). RESULTS: After AtDCS, accuracy of the word recognition memory task increased (prestimulation: 15.5 +/- 0.9, poststimulation: 17.9 +/- 0.8, p = 0.0068) whereas after CtDCS it decreased (15.8 +/- 0.6 vs 13.2 +/- 0.9, p = 0.011) and after StDCS it remained unchanged (16.3 +/- 0.7 vs 16.0 +/- 1.0, p = 0.75). tDCS left the visual attention-reaction times unchanged. CONCLUSION: Transcranial direct current stimulation (tDCS) delivered over the temporoparietal areas can specifically affect a recognition memory performance in patients with Alzheimer disease (AD). Because tDCS is simple, safe and inexpensive, our finding prompts studies using repeated tDCS, in conjunction with other therapeutic interventions for treating patients with AD. KW - kristina KW - memory KW - nichola AU - Ferrucci, R AU - Mameli, F AU - Guidi, I AU - Mrakic-Sposta, S AU - Vergari, M AU - Marceglia, S AU - Cogiamanian, F AU - Barbieri, S AU - Scarpini, E AU - Priori, A PY - 2008/06/04/ UR - http://dx.doi.org/10.1212/01.wnl.0000317060.43722.a3 ER -