Role of Layer 6 of V2 Visual Cortex in Object-Recognition Memory Export

@article{citeulike:5043896, abstract = {Cellular responses in the V2 secondary visual cortex to simple as well as complex visual stimuli have been well studied. However, the role of area V2 in visual memory remains unexplored. We found that layer 6 neurons of V2 are crucial for the processing of object-recognition memory (ORM). Using the protein regulator of G protein signaling-14 (RGS-14) as a tool, we found that the expression of this protein into layer 6 neurons of rat-brain area V2 promoted the conversion of a normal short-term ORM that normally lasts for 45 minutes into long-term memory detectable even after many months. Furthermore, elimination of the same-layer neurons by means of injection of a selective cytotoxin resulted in the complete loss of normal as well as protein-mediated enhanced ORM. 10.1126/science.1170869}, author = {Lopez-Aranda, Manuel F. and Lopez-Tellez, Juan F. and Navarro-Lobato, Irene and Masmudi-Martin, Mariam and Gutierrez, Antonia and Khan, Zafar U.}, citeulike-article-id = {5043896}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1170869}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/325/5936/87}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19574389}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19574389}, day = {3}, doi = {10.1126/science.1170869}, issn = {1095-9203}, journal = {Science}, keywords = {bob, jie, kristina, shiva}, month = {July}, number = {5936}, pages = {87--89}, posted-at = {2009-07-29 02:30:10}, priority = {2}, title = {Role of Layer 6 of V2 Visual Cortex in Object-Recognition Memory}, url = {http://dx.doi.org/10.1126/science.1170869}, volume = {325}, year = {2009} }

TY - JOUR ID - citeulike:5043896 L3 - citeulike-article-id:5043896 N2 - Cellular responses in the V2 secondary visual cortex to simple as well as complex visual stimuli have been well studied. However, the role of area V2 in visual memory remains unexplored. We found that layer 6 neurons of V2 are crucial for the processing of object-recognition memory (ORM). Using the protein regulator of G protein signaling-14 (RGS-14) as a tool, we found that the expression of this protein into layer 6 neurons of rat-brain area V2 promoted the conversion of a normal short-term ORM that normally lasts for 45 minutes into long-term memory detectable even after many months. Furthermore, elimination of the same-layer neurons by means of injection of a selective cytotoxin resulted in the complete loss of normal as well as protein-mediated enhanced ORM. 10.1126/science.1170869 IS - 5936 JF - Science SN - 1095-9203 EP - 89 TI - Role of Layer 6 of V2 Visual Cortex in Object-Recognition Memory VL - 325 SP - 87 KW - bob KW - jie KW - kristina KW - shiva AU - Lopez-Aranda, Manuel AU - Lopez-Tellez, Juan AU - Navarro-Lobato, Irene AU - Masmudi-Martin, Mariam AU - Gutierrez, Antonia AU - Khan, Zafar PY - 2009/07/03/ UR - http://dx.doi.org/10.1126/science.1170869 ER -