Effects of magnesium sulphate on intraoperative anaesthetic requirements and postoperative analgesia in gynaecology patients receiving total intravenous anaesthesia Export

@article{citeulike:2697692, abstract = {BackgroundThis randomized, double-blind, prospective study was undertaken to evaluate the effects of magnesium sulphate on anaesthetic requirements and postoperative analgesia in patients undergoing total i.v. anaesthesia (TIVA). MethodsFifty patients who underwent gynaecological surgery were randomly divided into two groups. Before induction of anaesthesia, the magnesium group (Group M) received magnesium sulphate 50 mg kg1 i.v. as a bolus and then 15 mg kg1 h1 i.v. by continuous infusion. The control group (Group S) received the same amount of isotonic saline. TIVA (propofol+remifentanil) was administered under bispectral index monitoring during anaesthesia induction and maintenance. Rocuronium was administered before orotracheal intubation and during surgery when the train-of-four count was 2 or more. After operation, patient-controlled analgesia with a solution of ketorolac and morphine was used and the consumption of this solution was recorded. Pain scores at rest and upon movement were evaluated 30 min, 4, 24, and 48 h after surgery. ResultsPatients in Group M required less rocuronium than those in Group S [mean (SD) 0.44 (0.09) vs 0.35 (0.07) {micro}g kg1 min1, P<0.05]. The total amounts of propofol and remifentanil administered were similar in the two groups. Postoperative pain scores, cumulative analgesic consumption, and shivering incidents were significantly lower in Group M (P<0.05). Mean arterial pressure just after intubation and during the immediate postoperative period was also significantly lower in Group M (P<0.05). ConclusionsI.V. magnesium sulphate during TIVA reduced rocuronium requirement and improved the quality of postoperative analgesia. 10.1093/bja/aem407}, author = {Ryu, J. H. and Kang, M. H. and Park, K. S. and Do, S. H.}, citeulike-article-id = {2697692}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/bja/aem407}, citeulike-linkout-1 = {http://bja.oxfordjournals.org/cgi/content/abstract/100/3/397}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18276652}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18276652}, day = {1}, doi = {10.1093/bja/aem407}, journal = {Br. J. Anaesth.}, keywords = {anaesthetic, analgesia, human, magnesium, march-08, mg, sparing, tiva}, month = {March}, number = {3}, pages = {397--403}, posted-at = {2008-04-21 19:30:26}, priority = {2}, title = {Effects of magnesium sulphate on intraoperative anaesthetic requirements and postoperative analgesia in gynaecology patients receiving total intravenous anaesthesia}, url = {http://dx.doi.org/10.1093/bja/aem407}, volume = {100}, year = {2008} }

TY - JOUR ID - citeulike:2697692 L3 - citeulike-article-id:2697692 N2 - BackgroundThis randomized, double-blind, prospective study was undertaken to evaluate the effects of magnesium sulphate on anaesthetic requirements and postoperative analgesia in patients undergoing total i.v. anaesthesia (TIVA). MethodsFifty patients who underwent gynaecological surgery were randomly divided into two groups. Before induction of anaesthesia, the magnesium group (Group M) received magnesium sulphate 50 mg kg1 i.v. as a bolus and then 15 mg kg1 h1 i.v. by continuous infusion. The control group (Group S) received the same amount of isotonic saline. TIVA (propofol+remifentanil) was administered under bispectral index monitoring during anaesthesia induction and maintenance. Rocuronium was administered before orotracheal intubation and during surgery when the train-of-four count was 2 or more. After operation, patient-controlled analgesia with a solution of ketorolac and morphine was used and the consumption of this solution was recorded. Pain scores at rest and upon movement were evaluated 30 min, 4, 24, and 48 h after surgery. ResultsPatients in Group M required less rocuronium than those in Group S [mean (SD) 0.44 (0.09) vs 0.35 (0.07) {micro}g kg1 min1, P<0.05]. The total amounts of propofol and remifentanil administered were similar in the two groups. Postoperative pain scores, cumulative analgesic consumption, and shivering incidents were significantly lower in Group M (P<0.05). Mean arterial pressure just after intubation and during the immediate postoperative period was also significantly lower in Group M (P<0.05). ConclusionsI.V. magnesium sulphate during TIVA reduced rocuronium requirement and improved the quality of postoperative analgesia. 10.1093/bja/aem407 IS - 3 JF - Br. J. Anaesth. EP - 403 TI - Effects of magnesium sulphate on intraoperative anaesthetic requirements and postoperative analgesia in gynaecology patients receiving total intravenous anaesthesia VL - 100 SP - 397 KW - anaesthetic KW - analgesia KW - human KW - magnesium KW - march-08 KW - mg KW - sparing KW - tiva AU - Ryu, JH AU - Kang, MH AU - Park, KS AU - Do, SH PY - 2008/03/01/ UR - http://dx.doi.org/10.1093/bja/aem407 ER -