Sex-Specific Responses to Opiates: Animal and Human Studies Export

@article{citeulike:3044773, abstract = {It is widely reported that analgesic drugs acting at {micro}, {kappa}, and {delta} opioid-receptors display quantitative and qualitative differences in effect in males and females. These sex-related differences are not restricted to the analgesic/antinociceptive properties of opioids, but are also present in opioid-induced side effects, such as changes in respiration, locomotor activity, learning/memory, addiction, and changes in the cardiovascular system. An increasing number of well-controlled animal and human studies directly examining the issue of sex in the potency of opioids show that, although sex may affect opioid analgesia, the direction and magnitude of sex differences depend on many interacting variables. These include those specific to the drug itself, such as dose, pharmacology, and route and time of administration, and those particular to the subject, such as species, type of pain, genetics, age, and gonadal/hormonal status. In the current review, we systematically present these animal and human studies and discuss the data in relation to the depending variables. Although the observed sex differences in opioid effect may be clinically relevant, lack of knowledge on other factors involved in the large variability in patient opioid analgesic sensitivity should compel practitioners to customize their dosing regimens based on individual requirements. 10.1213/ane.0b013e31816a66a4}, author = {Dahan, Albert and Kest, Benjamin and Waxman, Amanda R. and Sarton, Elise}, citeulike-article-id = {3044773}, citeulike-linkout-0 = {http://dx.doi.org/10.1213/ane.0b013e31816a66a4}, citeulike-linkout-1 = {http://www.anesthesia-analgesia.org/cgi/content/abstract/107/1/83}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18635471}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18635471}, doi = {10.1213/ane.0b013e31816a66a4}, journal = {Anesth Analg}, keywords = {gender, july-08, opioids, review}, month = {July}, number = {1}, pages = {83--95}, posted-at = {2008-07-26 15:58:51}, priority = {2}, title = {Sex-Specific Responses to Opiates: Animal and Human Studies}, url = {http://dx.doi.org/10.1213/ane.0b013e31816a66a4}, volume = {107}, year = {2008} }

TY - JOUR ID - citeulike:3044773 L3 - citeulike-article-id:3044773 N2 - It is widely reported that analgesic drugs acting at {micro}, {kappa}, and {delta} opioid-receptors display quantitative and qualitative differences in effect in males and females. These sex-related differences are not restricted to the analgesic/antinociceptive properties of opioids, but are also present in opioid-induced side effects, such as changes in respiration, locomotor activity, learning/memory, addiction, and changes in the cardiovascular system. An increasing number of well-controlled animal and human studies directly examining the issue of sex in the potency of opioids show that, although sex may affect opioid analgesia, the direction and magnitude of sex differences depend on many interacting variables. These include those specific to the drug itself, such as dose, pharmacology, and route and time of administration, and those particular to the subject, such as species, type of pain, genetics, age, and gonadal/hormonal status. In the current review, we systematically present these animal and human studies and discuss the data in relation to the depending variables. Although the observed sex differences in opioid effect may be clinically relevant, lack of knowledge on other factors involved in the large variability in patient opioid analgesic sensitivity should compel practitioners to customize their dosing regimens based on individual requirements. 10.1213/ane.0b013e31816a66a4 IS - 1 JF - Anesth Analg EP - 95 TI - Sex-Specific Responses to Opiates: Animal and Human Studies VL - 107 SP - 83 KW - gender KW - july-08 KW - opioids KW - review AU - Dahan, Albert AU - Kest, Benjamin AU - Waxman, Amanda AU - Sarton, Elise PY - 2008/07/01/ UR - http://dx.doi.org/10.1213/ane.0b013e31816a66a4 ER -