The influence of crystalloid type on acidbase and electrolyte status of cats with urethral obstruction Export

@article{citeulike:3151390, abstract = {Objective: To compare the effect of a balanced isotonic crystalloid solution with that of 0.9\% sodium chloride on the acid–base and electrolyte status of cats with urethral obstruction. Design: Randomized prospective clinical trial. Setting: Academic veterinary emergency room. Animals: Sixty-eight cats with naturally occurring urethral obstruction. Interventions: Cats were randomized to receive either a balanced isotonic crystalloid solution (Normosol-R, n=39) or 0.9\% sodium chloride (n=29) for fluid therapy. Baseline venous blood gas and blood electrolyte values were obtained at the time of admission and at intervals during the course of therapy. Measurements and main results: Baseline values were similar between groups. Cats receiving Normosol-R had a significantly higher blood pH at 12 hours, a significantly greater increase in blood pH from baseline at 6 and 12 hours, as well as a significantly higher blood bicarbonate concentration at 12 hours and a significantly greater increase in blood bicarbonate from baseline at 6 and 12 hours. Conversely, the increase in blood chloride from baseline was significantly higher at 2, 6, and 12 hours in cats receiving 0.9\% sodium chloride. There were no significant differences in the rate of decline of blood potassium from baseline between groups. Subgroup analysis of hyperkalemic cats (K+>6.0 mmol/L) and acidemic cats (pH<7.3) yielded similar findings. Conclusions: While both crystalloid solutions appear safe and effective for fluid therapy in cats with urethral obstruction, the use of a balanced electrolyte solution may allow more rapid correction of blood acid–base status within the first 12 hours of fluid therapy. The use of a potassium-containing balanced electrolyte solution does not appear to affect the rate of normalization of blood potassium in treated cats with urethral obstruction.}, author = {Drobatz and Kenneth, J. and Cole and Steven, G.}, citeulike-article-id = {3151390}, citeulike-linkout-0 = {http://dx.doi.org/10.1111/j.1476-4431.2008.00328.x}, citeulike-linkout-1 = {http://www.ingentaconnect.com/content/bsc/vec/2008/00000018/00000004/art00001}, doi = {10.1111/j.1476-4431.2008.00328.x}, issn = {1476-4431}, journal = {Journal of Veterinary Emergency and Critical Care}, keywords = {acid-base, august-08, crystalloid, fluid, status, type}, month = {August}, number = {4}, pages = {355--361}, posted-at = {2008-10-09 03:33:46}, priority = {2}, publisher = {Blackwell Publishing}, title = {The influence of crystalloid type on acidbase and electrolyte status of cats with urethral obstruction}, url = {http://dx.doi.org/10.1111/j.1476-4431.2008.00328.x}, volume = {18}, year = {2008} }

TY - JOUR ID - citeulike:3151390 L3 - citeulike-article-id:3151390 N2 - Objective: To compare the effect of a balanced isotonic crystalloid solution with that of 0.9% sodium chloride on the acid–base and electrolyte status of cats with urethral obstruction. Design: Randomized prospective clinical trial. Setting: Academic veterinary emergency room. Animals: Sixty-eight cats with naturally occurring urethral obstruction. Interventions: Cats were randomized to receive either a balanced isotonic crystalloid solution (Normosol-R, n=39) or 0.9% sodium chloride (n=29) for fluid therapy. Baseline venous blood gas and blood electrolyte values were obtained at the time of admission and at intervals during the course of therapy. Measurements and main results: Baseline values were similar between groups. Cats receiving Normosol-R had a significantly higher blood pH at 12 hours, a significantly greater increase in blood pH from baseline at 6 and 12 hours, as well as a significantly higher blood bicarbonate concentration at 12 hours and a significantly greater increase in blood bicarbonate from baseline at 6 and 12 hours. Conversely, the increase in blood chloride from baseline was significantly higher at 2, 6, and 12 hours in cats receiving 0.9% sodium chloride. There were no significant differences in the rate of decline of blood potassium from baseline between groups. Subgroup analysis of hyperkalemic cats (K+>6.0 mmol/L) and acidemic cats (pH<7.3) yielded similar findings. Conclusions: While both crystalloid solutions appear safe and effective for fluid therapy in cats with urethral obstruction, the use of a balanced electrolyte solution may allow more rapid correction of blood acid–base status within the first 12 hours of fluid therapy. The use of a potassium-containing balanced electrolyte solution does not appear to affect the rate of normalization of blood potassium in treated cats with urethral obstruction. IS - 4 JF - Journal of Veterinary Emergency and Critical Care SN - 1476-4431 EP - 361 TI - The influence of crystalloid type on acidbase and electrolyte status of cats with urethral obstruction PB - Blackwell Publishing VL - 18 SP - 355 KW - acid-base KW - august-08 KW - crystalloid KW - fluid KW - status KW - type AU - Drobatz AU - Kenneth, J AU - Cole AU - Steven, G PY - 2008/08// UR - http://dx.doi.org/10.1111/j.1476-4431.2008.00328.x ER -