Topical application of mitomycin C in combination with dexamethasone: effective delay of myringotomy closure. Export

@article{citeulike:2802587, abstract = {The object of this study was to investigate the efficacy of topical mitomycin C (MMC) in combination with subsequent topical dexamethasone to prolong the patency of myringotomies. Bilateral instrumental myringotomies were performed in 12 rats. On both sides, a solution of MMC (2 mg/ml) was applied to the intact tympanic membrane for ten minutes before myringotomy. Dexamethasone (4 mg/ml) was applied to one tympanic membrane of each animal at days 3, 6, 9 and 14. Tympanic membranes were observed weekly for a total of 9 weeks. The mean healing period was found to be 17.5 days (range 4.5-45.5 days) in the group with MMC alone, and 32 days (range 17.5-59.5 days) in the group MMC + dexamethasone. The difference was significant. A combination of topical MMC and subsequent dexamethasone did delay the healing rate of myringotomies in rat tympanic membranes longer than MMC alone.}, address = {Department of Otorhinolaryngology and Head and Neck Surgery, University of Greifswald, Greifswald, Germany. h.kaftan@web.de}, author = {Kaftan, H. and Hosemann, W.}, citeulike-article-id = {2802587}, citeulike-linkout-0 = {http://dx.doi.org/10.1159/000091393}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16479144}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16479144}, comment = {dexa 가 무슨 effect가 있어서 그럴까 싶기도 하고. mmc 와 dexa 바르는 걸 rat에나 하지 어느 세월에 사람에게 하나 싶다. }, doi = {10.1159/000091393}, issn = {0301-1569}, journal = {ORL; journal for oto-rhino-laryngology and its related specialties}, keywords = {lvt}, number = {4}, pages = {185--188}, posted-at = {2008-05-15 20:53:05}, priority = {2}, title = {Topical application of mitomycin C in combination with dexamethasone: effective delay of myringotomy closure.}, url = {http://dx.doi.org/10.1159/000091393}, volume = {68}, year = {2006} }

TY - JOUR ID - citeulike:2802587 L3 - citeulike-article-id:2802587 N2 - The object of this study was to investigate the efficacy of topical mitomycin C (MMC) in combination with subsequent topical dexamethasone to prolong the patency of myringotomies. Bilateral instrumental myringotomies were performed in 12 rats. On both sides, a solution of MMC (2 mg/ml) was applied to the intact tympanic membrane for ten minutes before myringotomy. Dexamethasone (4 mg/ml) was applied to one tympanic membrane of each animal at days 3, 6, 9 and 14. Tympanic membranes were observed weekly for a total of 9 weeks. The mean healing period was found to be 17.5 days (range 4.5-45.5 days) in the group with MMC alone, and 32 days (range 17.5-59.5 days) in the group MMC + dexamethasone. The difference was significant. A combination of topical MMC and subsequent dexamethasone did delay the healing rate of myringotomies in rat tympanic membranes longer than MMC alone. IS - 4 JF - ORL; journal for oto-rhino-laryngology and its related specialties SN - 0301-1569 AD - Department of Otorhinolaryngology and Head and Neck Surgery, University of Greifswald, Greifswald, Germany. h.kaftan@web.de EP - 188 TI - Topical application of mitomycin C in combination with dexamethasone: effective delay of myringotomy closure. VL - 68 SP - 185 KW - lvt N1 - dexa 가 무슨 effect가 있어서 그럴까 싶기도 하고. mmc 와 dexa 바르는 걸 rat에나 하지 어느 세월에 사람에게 하나 싶다. AU - Kaftan, H AU - Hosemann, W PY - 2006/// UR - http://dx.doi.org/10.1159/000091393 ER -