Prestin is the motor protein of cochlear outer hair cells. Export

@article{citeulike:2851593, abstract = {The outer and inner hair cells of the mammalian cochlea perform different functions. In response to changes in membrane potential, the cylindrical outer hair cell rapidly alters its length and stiffness. These mechanical changes, driven by putative molecular motors, are assumed to produce amplification of vibrations in the cochlea that are transduced by inner hair cells. Here we have identified an abundant complementary DNA from a gene, designated Prestin, which is specifically expressed in outer hair cells. Regions of the encoded protein show moderate sequence similarity to pendrin and related sulphate/anion transport proteins. Voltage-induced shape changes can be elicited in cultured human kidney cells that express prestin. The mechanical response of outer hair cells to voltage change is accompanied by a 'gating current', which is manifested as nonlinear capacitance. We also demonstrate this nonlinear capacitance in transfected kidney cells. We conclude that prestin is the motor protein of the cochlear outer hair cell.}, address = {The Hugh Knowles Center, Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA.}, author = {Zheng, J. and Shen, W. and He, D. Z. and Long, K. B. and Madison, L. D. and Dallos, P.}, citeulike-article-id = {2851593}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/35012009}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/10821263}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=10821263}, day = {11}, doi = {10.1038/35012009}, issn = {0028-0836}, journal = {Nature}, keywords = {ohc, pretin}, month = {May}, number = {6783}, pages = {149--155}, posted-at = {2008-05-31 02:22:33}, priority = {4}, title = {Prestin is the motor protein of cochlear outer hair cells.}, url = {http://dx.doi.org/10.1038/35012009}, volume = {405}, year = {2000} }

TY - JOUR ID - citeulike:2851593 L3 - citeulike-article-id:2851593 N2 - The outer and inner hair cells of the mammalian cochlea perform different functions. In response to changes in membrane potential, the cylindrical outer hair cell rapidly alters its length and stiffness. These mechanical changes, driven by putative molecular motors, are assumed to produce amplification of vibrations in the cochlea that are transduced by inner hair cells. Here we have identified an abundant complementary DNA from a gene, designated Prestin, which is specifically expressed in outer hair cells. Regions of the encoded protein show moderate sequence similarity to pendrin and related sulphate/anion transport proteins. Voltage-induced shape changes can be elicited in cultured human kidney cells that express prestin. The mechanical response of outer hair cells to voltage change is accompanied by a 'gating current', which is manifested as nonlinear capacitance. We also demonstrate this nonlinear capacitance in transfected kidney cells. We conclude that prestin is the motor protein of the cochlear outer hair cell. IS - 6783 JF - Nature SN - 0028-0836 AD - The Hugh Knowles Center, Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA. EP - 155 TI - Prestin is the motor protein of cochlear outer hair cells. VL - 405 SP - 149 KW - ohc KW - pretin AU - Zheng, J AU - Shen, W AU - He, DZ AU - Long, KB AU - Madison, LD AU - Dallos, P PY - 2000/05/11/ UR - http://dx.doi.org/10.1038/35012009 ER -