Curcumin Stimulates Proliferation of Embryonic Neural Progenitor Cells and Neurogenesis in the Adult Hippocampus

@article{citeulike:2814410, abstract = {Curcumin is a natural phenolic component of yellow curry spice, which is used in some cultures for the treatment of diseases associated with oxidative stress and inflammation. Curcumin has been reported to be capable of preventing the death of neurons in animal models of neurodegenerative disorders, but its possible effects on developmental and adult neuroplasticity are unknown. In the present study, we investigated the effects of curcumin on mouse multi-potent neural progenitor cells (NPC) and adult hippocampal neurogenesis. Curcumin exerted biphasic effects on cultured NPC; low concentrations stimulated cell proliferation, whereas high concentrations were cytotoxic. Curcumin activated extracellular signal-regulated kinases (ERKs) and p38 kinases, cellular signal transduction pathways known to be involved in the regulation of neuronal plasticity and stress responses. Inhibitors of ERKs and p38 kinases effectively blocked the mitogenic effect of curcumin in NPC. Administration of curcumin to adult mice resulted in a significant increase in the number of newly generated cells in the dentate gyrus of hippocampus, indicating that curcumin enhances adult hippocampal neurogenesis. Our findings suggest that curcumin can stimulate developmental and adult hippocampal neurogenesis, and a biological activity that may enhance neural plasticity and repair. 10.1074/jbc.M708373200}, author = {Kim, So J. and Son, Tae G. and Park, Hee R. and Park, Mikyung and Kim, Min-Sun and Kim, Hyung S. and Chung, Hae Y. and Mattson, Mark P. and Lee, Jaewon }, citeulike-article-id = {2814410}, doi = {10.1074/jbc.M708373200}, journal = {J. Biol. Chem.}, keywords = {curcuminneurogenesis}, month = {May}, number = {21}, pages = {14497--14505}, posted-at = {2008-05-20 02:22:55}, priority = {0}, title = {Curcumin Stimulates Proliferation of Embryonic Neural Progenitor Cells and Neurogenesis in the Adult Hippocampus}, url = {http://dx.doi.org/10.1074/jbc.M708373200}, volume = {283}, year = {2008} }

TY - JOUR ID - citeulike:2814410 L3 - citeulike-article-id:2814410 TI - Curcumin Stimulates Proliferation of Embryonic Neural Progenitor Cells and Neurogenesis in the Adult Hippocampus JF - J. Biol. Chem. VL - 283 IS - 21 SP - 14497 EP - 14505 N2 - Curcumin is a natural phenolic component of yellow curry spice, which is used in some cultures for the treatment of diseases associated with oxidative stress and inflammation. Curcumin has been reported to be capable of preventing the death of neurons in animal models of neurodegenerative disorders, but its possible effects on developmental and adult neuroplasticity are unknown. In the present study, we investigated the effects of curcumin on mouse multi-potent neural progenitor cells (NPC) and adult hippocampal neurogenesis. Curcumin exerted biphasic effects on cultured NPC; low concentrations stimulated cell proliferation, whereas high concentrations were cytotoxic. Curcumin activated extracellular signal-regulated kinases (ERKs) and p38 kinases, cellular signal transduction pathways known to be involved in the regulation of neuronal plasticity and stress responses. Inhibitors of ERKs and p38 kinases effectively blocked the mitogenic effect of curcumin in NPC. Administration of curcumin to adult mice resulted in a significant increase in the number of newly generated cells in the dentate gyrus of hippocampus, indicating that curcumin enhances adult hippocampal neurogenesis. Our findings suggest that curcumin can stimulate developmental and adult hippocampal neurogenesis, and a biological activity that may enhance neural plasticity and repair. 10.1074/jbc.M708373200 KW - curcuminneurogenesis AU - Kim, So AU - Son, Tae AU - Park, Hee AU - Park, Mikyung AU - Kim, Min-Sun AU - Kim, Hyung AU - Chung, Hae AU - Mattson, Mark AU - Lee, Jaewon PY - 2008/05/23/ UR - http://dx.doi.org/10.1074/jbc.M708373200 ER -