Topical acetone treatment induces neurogenic oedema on the sensitized mouse ear: an in vivo study using transient receptor potential vanilloid 1 (TRPV1) receptor knockout mice. Export

@article{citeulike:3199991, abstract = {OBJECTIVE: The participation of sensory neurons and transient receptor potential vanilloid 1 (TRPV1) receptors in phorbol 12-myristate 13-acetate (PMA)-induced nerve-sensitizing effect was examined. MATERIALS AND METHODS: PMA dissolved in acetone and acetone were applied to the ears of TRPV1 receptor knockout and wild-type mice. Different groups of animals received ibuprofen, anti-interleukin-1 beta (IL-1beta) antibody, resiniferatoxin (RTX) or capsaicin pretreatment. Ear thickness, myeloperoxidase activity and IL-1beta content of the ears were determined. Histological evaluation was performed. RESULTS: PMA exerted potentiating action on contralateral acetone-induced ear oedema, which was inhibited by ibuprofen, topical capsaicin desensitization of the acetone-treated ear as well as by systemic RTX pretreatment. Neither the lack of TRPV1 receptors nor anti-IL-1beta antibody prevented sensitizing effect. CONCLUSIONS: The TRPV1 receptor-independent potentiating action of PMA on contralateral acetone-induced ear oedema is mediated via capsaicin-sensitive afferents and prostanoids are involved. IL-1beta is not essential in this process.}, address = {Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of P\'{e}cs, P\'{e}cs, Hungary.}, author = {Pozsgai, G. and S\'{a}ndor, K. and Perkecz, A. and Szolcs\'{a}nyi, J. and Helyes, Z. and Brain, S. D. and Pint\'{e}r, E.}, citeulike-article-id = {3199991}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s00011-007-7065-7}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18224287}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18224287}, doi = {10.1007/s00011-007-7065-7}, issn = {1023-3830}, journal = {Inflammation research : official journal of the European Histamine Research Society ... [et al.]}, keywords = {acetone, trpv1}, month = {November}, number = {11}, pages = {459--467}, posted-at = {2008-09-06 21:22:45}, priority = {3}, title = {Topical acetone treatment induces neurogenic oedema on the sensitized mouse ear: an in vivo study using transient receptor potential vanilloid 1 (TRPV1) receptor knockout mice.}, url = {http://dx.doi.org/10.1007/s00011-007-7065-7}, volume = {56}, year = {2007} }

TY - JOUR ID - citeulike:3199991 L3 - citeulike-article-id:3199991 N2 - OBJECTIVE: The participation of sensory neurons and transient receptor potential vanilloid 1 (TRPV1) receptors in phorbol 12-myristate 13-acetate (PMA)-induced nerve-sensitizing effect was examined. MATERIALS AND METHODS: PMA dissolved in acetone and acetone were applied to the ears of TRPV1 receptor knockout and wild-type mice. Different groups of animals received ibuprofen, anti-interleukin-1 beta (IL-1beta) antibody, resiniferatoxin (RTX) or capsaicin pretreatment. Ear thickness, myeloperoxidase activity and IL-1beta content of the ears were determined. Histological evaluation was performed. RESULTS: PMA exerted potentiating action on contralateral acetone-induced ear oedema, which was inhibited by ibuprofen, topical capsaicin desensitization of the acetone-treated ear as well as by systemic RTX pretreatment. Neither the lack of TRPV1 receptors nor anti-IL-1beta antibody prevented sensitizing effect. CONCLUSIONS: The TRPV1 receptor-independent potentiating action of PMA on contralateral acetone-induced ear oedema is mediated via capsaicin-sensitive afferents and prostanoids are involved. IL-1beta is not essential in this process. IS - 11 JF - Inflammation research : official journal of the European Histamine Research Society ... [et al.] SN - 1023-3830 AD - Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pécs, Pécs, Hungary. EP - 467 TI - Topical acetone treatment induces neurogenic oedema on the sensitized mouse ear: an in vivo study using transient receptor potential vanilloid 1 (TRPV1) receptor knockout mice. VL - 56 SP - 459 KW - acetone KW - trpv1 AU - Pozsgai, G AU - Sándor, K AU - Perkecz, A AU - Szolcsányi, J AU - Helyes, Z AU - Brain, SD AU - Pintér, E PY - 2007/11// UR - http://dx.doi.org/10.1007/s00011-007-7065-7 ER -