Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway. Export

@article{citeulike:3496075, abstract = {The role of resveratrol and curcumin is well documented in cancer, inflammation, diabetes and various other diseases. However, their immunosuppressive action on T cells, B cells and macrophages is not well documented. In the present study, we have ascertained the effect of resveratrol and curcumin on T and B cells and macrophages. The most striking findings were that both resveratrol and curcumin suppressed the activity of T and B cells and macrophages, as evidenced by significant inhibition in proliferation, antibody production and lymphokine secretion. Interestingly, curcumin imparted immunosuppression by mainly down-regulating the expression of CD28 and CD80 and up-regulating CTLA-4. Resveratrol also functioned by decreasing the expression of CD28 and CD80, as well as by augmenting the production of interleukin (IL)-10.}, author = {Sharma, S. and Chopra, K. and Kulkarni, S. K. and Agrewala, J. N.}, citeulike-article-id = {3496075}, citeulike-linkout-0 = {http://dx.doi.org/10.1111/j.1365-2249.2006.03257.x}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17177975}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17177975}, doi = {10.1111/j.1365-2249.2006.03257.x}, issn = {0009-9104}, journal = {Clinical and experimental immunology}, keywords = {cd28ctla-4, cd80, curcumin, il10, resveratrol}, month = {January}, number = {1}, pages = {155--163}, posted-at = {2008-11-08 11:27:12}, priority = {3}, title = {Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway.}, url = {http://dx.doi.org/10.1111/j.1365-2249.2006.03257.x}, volume = {147}, year = {2007} }

TY - JOUR ID - citeulike:3496075 L3 - citeulike-article-id:3496075 N2 - The role of resveratrol and curcumin is well documented in cancer, inflammation, diabetes and various other diseases. However, their immunosuppressive action on T cells, B cells and macrophages is not well documented. In the present study, we have ascertained the effect of resveratrol and curcumin on T and B cells and macrophages. The most striking findings were that both resveratrol and curcumin suppressed the activity of T and B cells and macrophages, as evidenced by significant inhibition in proliferation, antibody production and lymphokine secretion. Interestingly, curcumin imparted immunosuppression by mainly down-regulating the expression of CD28 and CD80 and up-regulating CTLA-4. Resveratrol also functioned by decreasing the expression of CD28 and CD80, as well as by augmenting the production of interleukin (IL)-10. IS - 1 JF - Clinical and experimental immunology SN - 0009-9104 EP - 163 TI - Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway. VL - 147 SP - 155 KW - cd28ctla-4 KW - cd80 KW - curcumin KW - il10 KW - resveratrol AU - Sharma, S AU - Chopra, K AU - Kulkarni, SK AU - Agrewala, JN PY - 2007/01// UR - http://dx.doi.org/10.1111/j.1365-2249.2006.03257.x ER -