How lipids and proteins interact in a membrane: a molecular approach. Export

@article{citeulike:828263, abstract = {Membrane proteins in a biological membrane are surrounded by a shell or annulus of 'solvent' lipid molecules. These lipid molecules in general interact rather non-specifically with the protein molecules, although a few 'hot-spots' may be present on the protein where anionic lipids bind with high affinity. Because of the low structural specificity of most of the annular sites, the composition of the lipid annulus will be rather similar to the bulk lipid composition of the membrane. The structures of the solvent lipid molecules are important in determining the conformational state of a membrane protein, and hence its activity, through charge and hydrogen bonding interactions between the lipid headgroups and residues in the protein, and through hydrophobic matching between the protein and the surrounding lipid bilayer. Evidence is also accumulating for the presence of 'co-factor' lipid molecules binding with high specificity to membrane proteins, often between transmembrane alpha-helices, and often being essential for activity.}, address = {School of Biological Sciences, University of Southampton, Southampton, UK. agl@soton.ac.uk}, author = {Lee, A. G.}, citeulike-article-id = {828263}, citeulike-linkout-0 = {http://dx.doi.org/10.1039/b504527d}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16880984}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16880984}, citeulike-linkout-3 = {http://www.rsc.org/Publishing/Journals/article.asp?doi=b504527d}, doi = {10.1039/b504527d}, issn = {1742-206X}, journal = {Mol Biosyst}, keywords = {biology, lipids, membrane, molecular}, month = {September}, number = {3}, pages = {203--212}, posted-at = {2006-10-31 15:46:35}, priority = {2}, title = {How lipids and proteins interact in a membrane: a molecular approach.}, url = {http://dx.doi.org/10.1039/b504527d}, volume = {1}, year = {2005} }

TY - JOUR ID - citeulike:828263 L3 - citeulike-article-id:828263 N2 - Membrane proteins in a biological membrane are surrounded by a shell or annulus of 'solvent' lipid molecules. These lipid molecules in general interact rather non-specifically with the protein molecules, although a few 'hot-spots' may be present on the protein where anionic lipids bind with high affinity. Because of the low structural specificity of most of the annular sites, the composition of the lipid annulus will be rather similar to the bulk lipid composition of the membrane. The structures of the solvent lipid molecules are important in determining the conformational state of a membrane protein, and hence its activity, through charge and hydrogen bonding interactions between the lipid headgroups and residues in the protein, and through hydrophobic matching between the protein and the surrounding lipid bilayer. Evidence is also accumulating for the presence of 'co-factor' lipid molecules binding with high specificity to membrane proteins, often between transmembrane alpha-helices, and often being essential for activity. IS - 3 JF - Mol Biosyst SN - 1742-206X AD - School of Biological Sciences, University of Southampton, Southampton, UK. agl@soton.ac.uk EP - 212 TI - How lipids and proteins interact in a membrane: a molecular approach. VL - 1 SP - 203 KW - biology KW - lipids KW - membrane KW - molecular AU - Lee, AG PY - 2005/09// UR - http://dx.doi.org/10.1039/b504527d ER -