Seeding and Propagation of Untransformed Mouse Mammary Cells in the Lung Export

@article{citeulike:3172430, abstract = {Acquisition of metastatic ability by tumor cells is considered a late event in the evolution of malignant tumors. Here we report that untransformed mouse mammary cells, engineered to express inducible oncogenic transgenes: MYC and KrasD12, or polyoma middle T, and introduced into the systemic circulation of a mouse, can bypass transformation at the primary site and develop into metastatic pulmonary lesions upon immediate or delayed oncogene induction. Therefore, previously untransformed mammary cells may establish residence in the lung once they have entered the bloodstream, and may assume malignant growth upon oncogene activation. Mammary cells lacking oncogenic transgenes displayed a similar capacity for long-term residence in the lungs but did not form ectopic tumors. 10.1126/science.1161621}, author = {Podsypanina, Katrina and Du, Yi-Chieh N. and Jechlinger, Martin and Beverly, Levi J. and Hambardzumyan, Dolores and Varmus, Harold}, citeulike-article-id = {3172430}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1161621}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/1161621//}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18755941}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18755941}, day = {28}, doi = {10.1126/science.1161621}, journal = {Science}, keywords = {breast, cancer, cancer-crosstalk, lung, metastasis, propagation}, month = {August}, pages = {1161621+}, posted-at = {2008-08-29 15:15:38}, priority = {5}, title = {Seeding and Propagation of Untransformed Mouse Mammary Cells in the Lung}, url = {http://dx.doi.org/10.1126/science.1161621}, year = {2008} }

TY - JOUR ID - citeulike:3172430 L3 - citeulike-article-id:3172430 N2 - Acquisition of metastatic ability by tumor cells is considered a late event in the evolution of malignant tumors. Here we report that untransformed mouse mammary cells, engineered to express inducible oncogenic transgenes: MYC and KrasD12, or polyoma middle T, and introduced into the systemic circulation of a mouse, can bypass transformation at the primary site and develop into metastatic pulmonary lesions upon immediate or delayed oncogene induction. Therefore, previously untransformed mammary cells may establish residence in the lung once they have entered the bloodstream, and may assume malignant growth upon oncogene activation. Mammary cells lacking oncogenic transgenes displayed a similar capacity for long-term residence in the lungs but did not form ectopic tumors. 10.1126/science.1161621 JF - Science TI - Seeding and Propagation of Untransformed Mouse Mammary Cells in the Lung SP - 1161621 KW - breast KW - cancer KW - cancer-crosstalk KW - lung KW - metastasis KW - propagation AU - Podsypanina, Katrina AU - Du, Yi-Chieh AU - Jechlinger, Martin AU - Beverly, Levi AU - Hambardzumyan, Dolores AU - Varmus, Harold PY - 2008/08/28/ UR - http://dx.doi.org/10.1126/science.1161621 ER -