Abnormal frontal white matter tracts in bipolar disorder: a diffusion tensor imaging study Export

@article{citeulike:3083411, abstract = {Adler CM, Holland SK, Schmithorst V, Wilke M, Weiss KL, Pan H, Strakowski SM. Abnormal frontal white matter tracts in bipolar disorder: a diffusion tensor imaging study. Bipolar Disord 2004: 6: 1972013203. {\copyright} Blackwell Munksgaard, 2004Objectives:  Prefrontal white matter has been hypothesized to be integral to the pathophysiology of bipolar disorder. Recent morphometric studies however, have not observed changes in white matter in bipolar patients. We hypothesized that changes in prefrontal function in bipolar disorder, widely reported in the literature, may be related to a loss of white matter tract integrity with a resultant dysconnectivity syndrome. In this study we utilized diffusion tensor imaging (DTI) to examine prefrontal white matter in patients with bipolar disorder.Methods:  Nine patients with bipolar disorder and nine healthy controls were recruited. DTI and localizing anatomic data were acquired, and regions of interest (ROIs) identified in the prefrontal white matter at 15, 20, 25, and 30 mm superior to the anterior commissure (AC). Fractional anisotropy (FA) and trace apparent diffusion coefficient (TADC) were compared by ROI between study groups.Results:  The FA of ROIs 25 and 30 mm above the AC was significantly reduced in patients with bipolar disorder; FA of all ROIs showed high-medium to large effect sizes. No significant group differences were identified in TADC.Conclusions:  Our findings suggest that a loss of bundle coherence is present in prefrontal white matter. This loss of coherence may contribute to prefrontal cortical pathology in patients with bipolar disorder.}, address = {Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine; Imaging Research Center, Children's Hospital Medical Center, University of Cincinnati; Center for Imaging Research, University of Cincinnati College of Medicine; Department of Radiology, University of Cincinnati College of Medicine; Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, USA}, author = {Adler, Caleb M. and Holland, Scott K. and Schmithorst, Vince and Wilke, Marko and Weiss, Kenneth L. and Pan, Hai and Strakowski, Stephen M.}, citeulike-article-id = {3083411}, citeulike-linkout-0 = {http://dx.doi.org/10.1111/j.1399-5618.2004.00108.x}, citeulike-linkout-1 = {http://www3.interscience.wiley.com/cgi-bin/abstract/118809081/ABSTRACT}, doi = {10.1111/j.1399-5618.2004.00108.x}, journal = {Bipolar Disorders}, keywords = {brain, imaging, morphology, mri, psychiatry, statistics}, number = {3}, pages = {197--203}, posted-at = {2008-08-05 05:58:10}, priority = {2}, title = {Abnormal frontal white matter tracts in bipolar disorder: a diffusion tensor imaging study}, url = {http://dx.doi.org/10.1111/j.1399-5618.2004.00108.x}, volume = {6}, year = {2004} }

TY - JOUR ID - citeulike:3083411 L3 - citeulike-article-id:3083411 N2 - Adler CM, Holland SK, Schmithorst V, Wilke M, Weiss KL, Pan H, Strakowski SM. Abnormal frontal white matter tracts in bipolar disorder: a diffusion tensor imaging study. Bipolar Disord 2004: 6: 1972013203. © Blackwell Munksgaard, 2004Objectives:  Prefrontal white matter has been hypothesized to be integral to the pathophysiology of bipolar disorder. Recent morphometric studies however, have not observed changes in white matter in bipolar patients. We hypothesized that changes in prefrontal function in bipolar disorder, widely reported in the literature, may be related to a loss of white matter tract integrity with a resultant dysconnectivity syndrome. In this study we utilized diffusion tensor imaging (DTI) to examine prefrontal white matter in patients with bipolar disorder.Methods:  Nine patients with bipolar disorder and nine healthy controls were recruited. DTI and localizing anatomic data were acquired, and regions of interest (ROIs) identified in the prefrontal white matter at 15, 20, 25, and 30 mm superior to the anterior commissure (AC). Fractional anisotropy (FA) and trace apparent diffusion coefficient (TADC) were compared by ROI between study groups.Results:  The FA of ROIs 25 and 30 mm above the AC was significantly reduced in patients with bipolar disorder; FA of all ROIs showed high-medium to large effect sizes. No significant group differences were identified in TADC.Conclusions:  Our findings suggest that a loss of bundle coherence is present in prefrontal white matter. This loss of coherence may contribute to prefrontal cortical pathology in patients with bipolar disorder. IS - 3 JF - Bipolar Disorders AD - Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine; Imaging Research Center, Children's Hospital Medical Center, University of Cincinnati; Center for Imaging Research, University of Cincinnati College of Medicine; Department of Radiology, University of Cincinnati College of Medicine; Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, USA EP - 203 TI - Abnormal frontal white matter tracts in bipolar disorder: a diffusion tensor imaging study VL - 6 SP - 197 KW - brain KW - imaging KW - morphology KW - mri KW - psychiatry KW - statistics AU - Adler, Caleb AU - Holland, Scott AU - Schmithorst, Vince AU - Wilke, Marko AU - Weiss, Kenneth AU - Pan, Hai AU - Strakowski, Stephen PY - 2004/// UR - http://dx.doi.org/10.1111/j.1399-5618.2004.00108.x ER -