Reduced Foxp3 expression with increased cytomegalovirus-specific CTL in HTLV-I-associated myelopathy.

@article{citeulike:3038164, abstract = {Human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients show high immune responses to HTLV-I. However, it is unclear whether the cytotoxic T lymphocyte (CTL) responses to other chronic viruses also increase. We investigated the responses in the peripheral blood by using HLA-A*0201/peptide pentamers. The frequency of cytomegalovirus (CMV)-specific CTL tended to be higher in HAM/TSP patients than in healthy controls (HCs). The frequency of CMV-specific CTL positively correlated with that of HTLV-I Tax-specific CTL. The frequency of Foxp3+ cells in CD4+ lymphocytes tended to be higher in HAM/TSP patients than in ACs and HCs. The expression level of Foxp3 was lower in HAM/TSP patients than in HCs and was inversely correlated with the CMV-specific CTL frequency. A percentage of Foxp3+ cells showed a positive correlation with the HTLV-I proviral load. These results suggest that a decrease in the Foxp3 expression may contribute to the high immune response to CMV and that the Foxp3+ regulatory T cells may play a role in the immune surveillance of HTLV-I.}, address = {Department of Neurology and Geriatrics, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan.}, author = {Hayashi, Daisuke and Kubota, Ryuji and Takenouchi, Norihiro and Tanaka, Yuetsu and Hirano, Ryuki and Takashima, Hiroshi and Osame, Mitsuhiro and Izumo, Shuji and Arimura, Kimiyoshi }, citeulike-article-id = {3038164}, doi = {http://dx.doi.org/10.1016/j.jneuroim.2008.06.005}, issn = {0165-5728}, journal = {Journal of neuroimmunology}, keywords = {c, cd8\_t\_cell, cmv, foxp3, hamtsp, htlv-1\_pvl, without\_pdf}, month = {July}, posted-at = {2008-07-24 04:08:00}, priority = {2}, title = {Reduced Foxp3 expression with increased cytomegalovirus-specific CTL in HTLV-I-associated myelopathy.}, url = {http://dx.doi.org/10.1016/j.jneuroim.2008.06.005}, year = {2008} }

TY - JOUR ID - citeulike:3038164 L3 - citeulike-article-id:3038164 TI - Reduced Foxp3 expression with increased cytomegalovirus-specific CTL in HTLV-I-associated myelopathy. JF - Journal of neuroimmunology AD - Department of Neurology and Geriatrics, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan. SN - 0165-5728 N2 - Human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients show high immune responses to HTLV-I. However, it is unclear whether the cytotoxic T lymphocyte (CTL) responses to other chronic viruses also increase. We investigated the responses in the peripheral blood by using HLA-A*0201/peptide pentamers. The frequency of cytomegalovirus (CMV)-specific CTL tended to be higher in HAM/TSP patients than in healthy controls (HCs). The frequency of CMV-specific CTL positively correlated with that of HTLV-I Tax-specific CTL. The frequency of Foxp3+ cells in CD4+ lymphocytes tended to be higher in HAM/TSP patients than in ACs and HCs. The expression level of Foxp3 was lower in HAM/TSP patients than in HCs and was inversely correlated with the CMV-specific CTL frequency. A percentage of Foxp3+ cells showed a positive correlation with the HTLV-I proviral load. These results suggest that a decrease in the Foxp3 expression may contribute to the high immune response to CMV and that the Foxp3+ regulatory T cells may play a role in the immune surveillance of HTLV-I. KW - c KW - cd8_t_cell KW - cmv KW - foxp3 KW - hamtsp KW - htlv-1_pvl KW - without_pdf AU - Hayashi, Daisuke AU - Kubota, Ryuji AU - Takenouchi, Norihiro AU - Tanaka, Yuetsu AU - Hirano, Ryuki AU - Takashima, Hiroshi AU - Osame, Mitsuhiro AU - Izumo, Shuji AU - Arimura, Kimiyoshi PY - 2008/07/16/ UR - http://dx.doi.org/10.1016/j.jneuroim.2008.06.005 ER -