Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Export

@article{citeulike:4180014, abstract = {Twelve outpatients, all women, who fulfilled the criteria for both fibromyalgia and chronic fatigue syndrome were rated on 15 items of the Comprehensive Psychopathological Rating Scale (CPRS-15). These items were chosen to constitute a proper neurasthenic subscale. Blood laboratory levels were generally normal. The most obvious finding was that, in all the patients, the homocysteine (HCY) levels were increased in the cerebrospinal fluid (CSF). There was a significant positive correlation between CSF-HCY levels and fatiguability, and the levels of CSF-B12 correlated significantly with the item of fatiguability and with CPRS-15. The correlations between vitamin B12 and clinical variables of the CPRS-scale in this study indicate that low CSF-B12 values are of clinical importance. Vitamin B12 deficiency causes a deficient remethylation of HCY and is therefore probably contributing to the increased homocysteine levels found in our patient group. We conclude that increased homocysteine levels in the central nervous system characterize patients fulfilling the criteria for both fibromyalgia and chronic fatigue syndrome.}, author = {Regland, B. and Andersson, M. and Abrahamsson, L. and Bagby, J. and Dyrehag, L. E. and Gottfries, C. G.}, citeulike-article-id = {4180014}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/9310111}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=9310111}, issn = {0300-9742}, journal = {Scandinavian journal of rheumatology}, keywords = {cfs, chronic\_fatigue\_syndrome, fibromyalgia, homocysteine}, number = {4}, pages = {301--307}, posted-at = {2009-03-16 00:05:04}, priority = {3}, title = {Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/9310111}, volume = {26}, year = {1997} }

TY - JOUR ID - citeulike:4180014 L3 - citeulike-article-id:4180014 N2 - Twelve outpatients, all women, who fulfilled the criteria for both fibromyalgia and chronic fatigue syndrome were rated on 15 items of the Comprehensive Psychopathological Rating Scale (CPRS-15). These items were chosen to constitute a proper neurasthenic subscale. Blood laboratory levels were generally normal. The most obvious finding was that, in all the patients, the homocysteine (HCY) levels were increased in the cerebrospinal fluid (CSF). There was a significant positive correlation between CSF-HCY levels and fatiguability, and the levels of CSF-B12 correlated significantly with the item of fatiguability and with CPRS-15. The correlations between vitamin B12 and clinical variables of the CPRS-scale in this study indicate that low CSF-B12 values are of clinical importance. Vitamin B12 deficiency causes a deficient remethylation of HCY and is therefore probably contributing to the increased homocysteine levels found in our patient group. We conclude that increased homocysteine levels in the central nervous system characterize patients fulfilling the criteria for both fibromyalgia and chronic fatigue syndrome. IS - 4 JF - Scandinavian journal of rheumatology SN - 0300-9742 EP - 307 TI - Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. VL - 26 SP - 301 KW - cfs KW - chronic_fatigue_syndrome KW - fibromyalgia KW - homocysteine AU - Regland, B AU - Andersson, M AU - Abrahamsson, L AU - Bagby, J AU - Dyrehag, LE AU - Gottfries, CG PY - 1997/// UR - http://view.ncbi.nlm.nih.gov/pubmed/9310111 ER -