Antiinflammatory and antihyperalgesic activity of C-phycocyanin. Export

@article{citeulike:4221887, abstract = {BACKGROUND: C-phycocyanin (C-PC), a biliprotein found in blue green algae, such as Spirulina platensis, is often used as a dietary nutritional supplement due to its various therapeutic values. In addition, the antiinflammatory activity of C-PC partly through inhibition of proinflammatory cytokine formation, inducible nitric oxide synthase (iNOS) and cyclooxygeanase-2 (COX-2) expression has been demonstrated in many in vitro and in vivo studies. However, whether C-PC also has antihyperalgesic activity in inflammatory nociception has not been investigated. METHODS: Using a carrageenan-induced thermal hyperalgesia model, we evaluated the effect of C-PC on nociception by measuring paw withdrawal latency. To clarify the mechanisms involved, the expression of iNOS and COX-2 and the formation of nitrate and tumor necrosis factor-alpha (TNF-alpha) in the rat paw were determined. RESULTS: Pre- or posttreatment with C-PC (30 or 50 mg/kg, IP) significantly attenuated carrageenan-induced inflammatory nociception and the induction of iNOS and COX-2 at the late phase, (4 h) accompanied by an inhibition of the formation of TNF-alpha, prostaglandin E(2), nitrate and myeloperoxidase activity. CONCLUSIONS: Based on these results, it is suggested that the inhibition of NO and prostaglandin E(2) over-production through suppressing iNOS and COX-2 induction and attenuation of TNF-alpha formation and neutrophil infiltration into inflammatory sites by C-PC may contribute, at least in part, to its antihyperalgesic activity.}, author = {Shih, C. M. and Cheng, S. N. and Wong, C. S. and Kuo, Y. L. and Chou, T. C.}, citeulike-article-id = {4221887}, citeulike-linkout-0 = {http://dx.doi.org/10.1213/ane.0b013e318193e919}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19299804}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19299804}, doi = {10.1213/ane.0b013e318193e919}, issn = {1526-7598}, journal = {Anesthesia and analgesia}, keywords = {antihyperalgesic, c-phycocyanin, inflammation, vitamins}, month = {April}, number = {4}, pages = {1303--1310}, posted-at = {2009-03-26 11:01:46}, priority = {3}, title = {Antiinflammatory and antihyperalgesic activity of C-phycocyanin.}, url = {http://dx.doi.org/10.1213/ane.0b013e318193e919}, volume = {108}, year = {2009} }

TY - JOUR ID - citeulike:4221887 L3 - citeulike-article-id:4221887 N2 - BACKGROUND: C-phycocyanin (C-PC), a biliprotein found in blue green algae, such as Spirulina platensis, is often used as a dietary nutritional supplement due to its various therapeutic values. In addition, the antiinflammatory activity of C-PC partly through inhibition of proinflammatory cytokine formation, inducible nitric oxide synthase (iNOS) and cyclooxygeanase-2 (COX-2) expression has been demonstrated in many in vitro and in vivo studies. However, whether C-PC also has antihyperalgesic activity in inflammatory nociception has not been investigated. METHODS: Using a carrageenan-induced thermal hyperalgesia model, we evaluated the effect of C-PC on nociception by measuring paw withdrawal latency. To clarify the mechanisms involved, the expression of iNOS and COX-2 and the formation of nitrate and tumor necrosis factor-alpha (TNF-alpha) in the rat paw were determined. RESULTS: Pre- or posttreatment with C-PC (30 or 50 mg/kg, IP) significantly attenuated carrageenan-induced inflammatory nociception and the induction of iNOS and COX-2 at the late phase, (4 h) accompanied by an inhibition of the formation of TNF-alpha, prostaglandin E(2), nitrate and myeloperoxidase activity. CONCLUSIONS: Based on these results, it is suggested that the inhibition of NO and prostaglandin E(2) over-production through suppressing iNOS and COX-2 induction and attenuation of TNF-alpha formation and neutrophil infiltration into inflammatory sites by C-PC may contribute, at least in part, to its antihyperalgesic activity. IS - 4 JF - Anesthesia and analgesia SN - 1526-7598 EP - 1310 TI - Antiinflammatory and antihyperalgesic activity of C-phycocyanin. VL - 108 SP - 1303 KW - antihyperalgesic KW - c-phycocyanin KW - inflammation KW - vitamins AU - Shih, CM AU - Cheng, SN AU - Wong, CS AU - Kuo, YL AU - Chou, TC PY - 2009/04// UR - http://dx.doi.org/10.1213/ane.0b013e318193e919 ER -