Effects of Coffee on Inflammatory Cytokine Gene Expression in Mice Fed High-Fat Diets Export

@article{citeulike:6090988, abstract = {In order to investigate the risk-reducing effects of coffee in metabolic syndrome, we performed a study in mice fed a high-fat diet with added coffee and analyzed gene expression in liver and adipose tissues using cDNA microarray. Male C57BL/6J mice were raised for 8 weeks on either a normal diet (N group), a high-fat diet (HF group), or a high-fat diet with 1.1\% decaffeinated (HF+DC group) or 1.1\% caffeine-containing instant coffee (HF+CC group). The body weights of mice in the HF+DC and HF+CC groups were mostly intermediate between the N and HF groups, even if there were no difference in the amount of diet consumption in each group. Mesenteric fat weight was lower in the HF+DC group than in the HF group (p < 0.05) and tended to become lower in the HF+CC group than in the HF group. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were significantly lower in the HF+DC and HF+CC groups than in the HF group (p < 0.05). Inflammatory cytokine interleukin (IL)-1β gene expression in liver was up-regulated in the HF group and significantly down-regulated in the HF+DC and HF+CC groups (p < 0.01), while MCP-1 gene expression in white adipose tissue was also significantly suppressed in the HF+DC group (p < 0.01). The induction of these anti-inflammatory responses by coffee consumption may contribute to reducing the risks of metabolic syndrome.}, author = {Fukushima, Yoichi and Kasuga, Masato and Nakao, Kazuwa and Shimomura, Iichiro and Matsuzawa, Yuji}, citeulike-article-id = {6090988}, citeulike-linkout-0 = {http://dx.doi.org/10.1021/jf901278u}, citeulike-linkout-1 = {http://pubs.acs.org/doi/abs/10.1021/jf901278u}, doi = {10.1021/jf901278u}, journal = {Journal of Agricultural and Food Chemistry}, number = {0}, posted-at = {2009-11-10 00:33:19}, priority = {3}, title = {Effects of Coffee on Inflammatory Cytokine Gene Expression in Mice Fed High-Fat Diets}, url = {http://dx.doi.org/10.1021/jf901278u}, volume = {0}, year = {0000} }

TY - JOUR ID - citeulike:6090988 L3 - citeulike-article-id:6090988 N2 - In order to investigate the risk-reducing effects of coffee in metabolic syndrome, we performed a study in mice fed a high-fat diet with added coffee and analyzed gene expression in liver and adipose tissues using cDNA microarray. Male C57BL/6J mice were raised for 8 weeks on either a normal diet (N group), a high-fat diet (HF group), or a high-fat diet with 1.1% decaffeinated (HF+DC group) or 1.1% caffeine-containing instant coffee (HF+CC group). The body weights of mice in the HF+DC and HF+CC groups were mostly intermediate between the N and HF groups, even if there were no difference in the amount of diet consumption in each group. Mesenteric fat weight was lower in the HF+DC group than in the HF group (p < 0.05) and tended to become lower in the HF+CC group than in the HF group. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were significantly lower in the HF+DC and HF+CC groups than in the HF group (p < 0.05). Inflammatory cytokine interleukin (IL)-1β gene expression in liver was up-regulated in the HF group and significantly down-regulated in the HF+DC and HF+CC groups (p < 0.01), while MCP-1 gene expression in white adipose tissue was also significantly suppressed in the HF+DC group (p < 0.01). The induction of these anti-inflammatory responses by coffee consumption may contribute to reducing the risks of metabolic syndrome. IS - 0 JF - Journal of Agricultural and Food Chemistry TI - Effects of Coffee on Inflammatory Cytokine Gene Expression in Mice Fed High-Fat Diets VL - 0 AU - Fukushima, Yoichi AU - Kasuga, Masato AU - Nakao, Kazuwa AU - Shimomura, Iichiro AU - Matsuzawa, Yuji PY - 2000/// UR - http://dx.doi.org/10.1021/jf901278u ER -