Iron and calcium in the central nervous system: a close relationship in health and sickness. Export

@article{citeulike:3680781, abstract = {Iron and calcium are required for general cellular functions, as well as for specific neuronal-related activities. However, a pathological increase in their levels favours oxidative stress and mitochondrial damage, leading to neuronal death. Neurodegeneration can thus be determined by alterations in ionic homoeostasis and/or pro-oxidative-antioxidative equilibrium, two conditions that vary significantly in different kinds of brain cell and also with aging. In the present review, we re-evaluate recent data on NTBI (non-transferrin bound iron) uptake that suggest a strict interplay with the mechanisms of calcium control. In particular, we focus on the use of common entry pathways and on the way cytosolic calcium can modulate iron entry and determine its intracellular accumulation.}, author = {Pelizzoni, Ilaria and Macco, Romina and Zacchetti, Daniele and Grohovaz, Fabio and Codazzi, Franca}, citeulike-article-id = {3680781}, citeulike-linkout-0 = {http://dx.doi.org/10.1042/BST0361309}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19021546}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19021546}, day = {1}, doi = {10.1042/BST0361309}, issn = {1470-8752}, journal = {Biochemical Society transactions}, keywords = {calcium, cns, iron, pathology}, month = {December}, number = {6}, pages = {1309--1312}, posted-at = {2008-11-24 12:39:35}, priority = {3}, title = {Iron and calcium in the central nervous system: a close relationship in health and sickness.}, url = {http://dx.doi.org/10.1042/BST0361309}, volume = {36}, year = {2008} }

TY - JOUR ID - citeulike:3680781 L3 - citeulike-article-id:3680781 N2 - Iron and calcium are required for general cellular functions, as well as for specific neuronal-related activities. However, a pathological increase in their levels favours oxidative stress and mitochondrial damage, leading to neuronal death. Neurodegeneration can thus be determined by alterations in ionic homoeostasis and/or pro-oxidative-antioxidative equilibrium, two conditions that vary significantly in different kinds of brain cell and also with aging. In the present review, we re-evaluate recent data on NTBI (non-transferrin bound iron) uptake that suggest a strict interplay with the mechanisms of calcium control. In particular, we focus on the use of common entry pathways and on the way cytosolic calcium can modulate iron entry and determine its intracellular accumulation. IS - 6 JF - Biochemical Society transactions SN - 1470-8752 EP - 1312 TI - Iron and calcium in the central nervous system: a close relationship in health and sickness. VL - 36 SP - 1309 KW - calcium KW - cns KW - iron KW - pathology AU - Pelizzoni, Ilaria AU - Macco, Romina AU - Zacchetti, Daniele AU - Grohovaz, Fabio AU - Codazzi, Franca PY - 2008/12/01/ UR - http://dx.doi.org/10.1042/BST0361309 ER -