Lead-induced alterations of apoptosis and neurotrophic factor mRNA in the developing rat cortex, hippocampus, and cerebellum. Export

@article{citeulike:4269746, abstract = {Previous reports have recently shown the prototypic neurotoxicant, lead, to induce apoptosis in the brains of developing organisms. In the current study, timed-pregnant rats were exposed to lead acetate (0.2\% in the drinking water) 24 h following birth at postnatal day 1 (PND 1). Dams and pups were continuously exposed to lead through the drinking water of the dam until PND 20. Postnatal exposure in the pups resulted in altered mRNA levels of the following apoptotic and neurotrophic factors: caspase 2 and 3, bax, bcl-x, brain-derived neurotrophic factor (BDNF). Ribonuclease protection assays were conducted to measure the factors simultaneously at the following postnatal time points: 9, 12, 15, 20, 25, days. Our results suggest a brain region- and time-specific response following lead acetate exposure. The region most vulnerable to alterations occurs in the hippocampus with alterations beginning at PND 12, in which caspase 3, bcl-x, BDNF increase with lead exposure. Significant treatment effects were not observed for both the cortex and cerebellum.}, author = {Chao, S. L. and Moss, J. M. and Harry, G. J.}, citeulike-article-id = {4269746}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/jbt.20191}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17912701}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17912701}, doi = {10.1002/jbt.20191}, issn = {1095-6670}, journal = {Journal of biochemical and molecular toxicology}, keywords = {bdnf, cerebellum, hippocampus, lead}, number = {5}, pages = {265--272}, posted-at = {2009-04-03 12:41:03}, priority = {3}, title = {Lead-induced alterations of apoptosis and neurotrophic factor mRNA in the developing rat cortex, hippocampus, and cerebellum.}, url = {http://dx.doi.org/10.1002/jbt.20191}, volume = {21}, year = {2007} }

TY - JOUR ID - citeulike:4269746 L3 - citeulike-article-id:4269746 N2 - Previous reports have recently shown the prototypic neurotoxicant, lead, to induce apoptosis in the brains of developing organisms. In the current study, timed-pregnant rats were exposed to lead acetate (0.2% in the drinking water) 24 h following birth at postnatal day 1 (PND 1). Dams and pups were continuously exposed to lead through the drinking water of the dam until PND 20. Postnatal exposure in the pups resulted in altered mRNA levels of the following apoptotic and neurotrophic factors: caspase 2 and 3, bax, bcl-x, brain-derived neurotrophic factor (BDNF). Ribonuclease protection assays were conducted to measure the factors simultaneously at the following postnatal time points: 9, 12, 15, 20, 25, days. Our results suggest a brain region- and time-specific response following lead acetate exposure. The region most vulnerable to alterations occurs in the hippocampus with alterations beginning at PND 12, in which caspase 3, bcl-x, BDNF increase with lead exposure. Significant treatment effects were not observed for both the cortex and cerebellum. IS - 5 JF - Journal of biochemical and molecular toxicology SN - 1095-6670 EP - 272 TI - Lead-induced alterations of apoptosis and neurotrophic factor mRNA in the developing rat cortex, hippocampus, and cerebellum. VL - 21 SP - 265 KW - bdnf KW - cerebellum KW - hippocampus KW - lead AU - Chao, SL AU - Moss, JM AU - Harry, GJ PY - 2007/// UR - http://dx.doi.org/10.1002/jbt.20191 ER -