Heavy metal ion-induced insulin-mimetic signaling. Export

@article{citeulike:5494841, abstract = {The serine/threonine kinase Akt is a mediator of insulin effects on target cells and, as such, is a major regulator of fuel metabolism. Akt was demonstrated to be activated in a phosphoinositide 3'-kinase-dependent fashion by stressful stimuli, including reactive oxygen species (ROS) and certain heavy metal ions. This minireview focuses on activation of the PI3K/Akt signaling cascade by exposure of cells to transition metal ions, such as Cu(II), Zn(II) or Ni(II), and discusses potential mechanisms of Akt activation and the role of ROS therein and consequences for signaling processes downstream of Akt, including modulation of FoxO-family transcription factors. In addition, we speculate on the significance of these findings with respect to processes with which FoxO proteins are known to be involved, i.e. stress-induced senescence and selenium homeostasis.}, author = {Eckers, Anna and Klotz, Lars-Oliver O.}, citeulike-article-id = {5494841}, citeulike-linkout-0 = {http://dx.doi.org/10.1179/135100009X392610}, citeulike-linkout-1 = {http://www.ingentaconnect.com/content/maney/rer/2009/00000014/00000004/art00001}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19695120}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19695120}, doi = {10.1179/135100009X392610}, issn = {1743-2928}, journal = {Redox report : communications in free radical research}, number = {4}, pages = {141--146}, posted-at = {2009-08-24 16:00:29}, priority = {3}, publisher = {Maney Publishing}, title = {Heavy metal ion-induced insulin-mimetic signaling.}, url = {http://dx.doi.org/10.1179/135100009X392610}, volume = {14}, year = {2009} }

TY - JOUR ID - citeulike:5494841 L3 - citeulike-article-id:5494841 N2 - The serine/threonine kinase Akt is a mediator of insulin effects on target cells and, as such, is a major regulator of fuel metabolism. Akt was demonstrated to be activated in a phosphoinositide 3'-kinase-dependent fashion by stressful stimuli, including reactive oxygen species (ROS) and certain heavy metal ions. This minireview focuses on activation of the PI3K/Akt signaling cascade by exposure of cells to transition metal ions, such as Cu(II), Zn(II) or Ni(II), and discusses potential mechanisms of Akt activation and the role of ROS therein and consequences for signaling processes downstream of Akt, including modulation of FoxO-family transcription factors. In addition, we speculate on the significance of these findings with respect to processes with which FoxO proteins are known to be involved, i.e. stress-induced senescence and selenium homeostasis. IS - 4 JF - Redox report : communications in free radical research SN - 1743-2928 EP - 146 TI - Heavy metal ion-induced insulin-mimetic signaling. PB - Maney Publishing VL - 14 SP - 141 AU - Eckers, Anna AU - Klotz, Lars-Oliver PY - 2009/// UR - http://dx.doi.org/10.1179/135100009X392610 ER -