Echinacea in infection Export

@article{citeulike:3293295, abstract = {Ongoing studies have developed strategies for identifying key bioactive compounds and chemical profiles in Echinacea with the goal of improving its human health benefits. Antiviral and antiinflammatory–antipain assays have targeted various classes of chemicals responsible for these activities. Analysis of polar fractions of E. purpurea extracts showed the presence of antiviral activity, with evidence suggesting that polyphenolic compounds other than the known HIV inhibitor, cichoric acid, may be involved. Antiinflammatory activity differed by species, with E. sanguinea having the greatest activity and E. angustifolia, E. pallida, and E. simulata having somewhat less. Fractionation and studies with pure compounds indicate that this activity is explained, at least in part, by the alkamide constituents. Ethanol extracts from Echinacea roots had potent activity as novel agonists of TRPV1, a mammalian pain receptor reported as an integrator of inflammatory pain and hyperalgesia and a prime therapeutic target for analgesic and antiinflammatory drugs. One fraction from E. purpurea ethanol extract was bioactive in this system. Interestingly, the antiinflammatory compounds identified to inhibit prostaglandin E2 production differed from those involved in TRPV1 receptor activation.}, author = {Birt, Diane F. and Widrlechner, Mark P. and Lalone, Carlie A. and Wu, Lankun and Bae, Jaehoon and Solco, Avery K. S. and Kraus, George A. and Murphy, Patricia A. and Wurtele, Eve S. and Leng, Qiang and Hebert, Steven C. and Maury, Wendy J. and Price, Jason P.}, citeulike-article-id = {3293295}, journal = {American Journal of Clinical Nutrition}, keywords = {acid, alkamide, antiinflammatory, antipain, antiviral, cichoric, echinacea, echinacea\_angustifolia, echinacea\_pallida, echinacea\_purpureaechinacea\_sanguinea, echinacea\_simulate, hivtrpv1\_receptor}, month = {February}, number = {2}, pages = {488S--492S}, posted-at = {2008-09-19 16:31:36}, priority = {3}, title = {Echinacea in infection}, volume = {87}, year = {2008} }

TY - JOUR ID - citeulike:3293295 L3 - citeulike-article-id:3293295 N2 - Ongoing studies have developed strategies for identifying key bioactive compounds and chemical profiles in Echinacea with the goal of improving its human health benefits. Antiviral and antiinflammatory–antipain assays have targeted various classes of chemicals responsible for these activities. Analysis of polar fractions of E. purpurea extracts showed the presence of antiviral activity, with evidence suggesting that polyphenolic compounds other than the known HIV inhibitor, cichoric acid, may be involved. Antiinflammatory activity differed by species, with E. sanguinea having the greatest activity and E. angustifolia, E. pallida, and E. simulata having somewhat less. Fractionation and studies with pure compounds indicate that this activity is explained, at least in part, by the alkamide constituents. Ethanol extracts from Echinacea roots had potent activity as novel agonists of TRPV1, a mammalian pain receptor reported as an integrator of inflammatory pain and hyperalgesia and a prime therapeutic target for analgesic and antiinflammatory drugs. One fraction from E. purpurea ethanol extract was bioactive in this system. Interestingly, the antiinflammatory compounds identified to inhibit prostaglandin E2 production differed from those involved in TRPV1 receptor activation. IS - 2 JF - American Journal of Clinical Nutrition EP - 492S TI - Echinacea in infection VL - 87 SP - 488S KW - acid KW - alkamide KW - antiinflammatory KW - antipain KW - antiviral KW - cichoric KW - echinacea KW - echinacea_angustifolia KW - echinacea_pallida KW - echinacea_purpureaechinacea_sanguinea KW - echinacea_simulate KW - hivtrpv1_receptor AU - Birt, Diane AU - Widrlechner, Mark AU - Lalone, Carlie AU - Wu, Lankun AU - Bae, Jaehoon AU - Solco, Avery AU - Kraus, George AU - Murphy, Patricia AU - Wurtele, Eve AU - Leng, Qiang AU - Hebert, Steven AU - Maury, Wendy AU - Price, Jason PY - 2008/02// ER -