Interaction of GABA and volatile anesthetics in the nematode Caenorhabditis elegans. Export

@article{citeulike:3275667, abstract = {The authors tested whether mutant strains of Caenorhabditis elegans with altered sensitivity to volatile anesthetics have altered responses to GABA or GABA-agonists. They determined the ED50s of the wild-type strain N2 and two mutant strains of C. elegans to a GABA-mimetic ivermectin (IVM) and to GABA. unc-79, a strain with increased sensitivity to halothane, was more sensitive than N2 to IVM and GABA. unc-9, a strain that suppresses the increased sensitivity of unc-79 to halothane, was less sensitive than N2 to IVM and GABA. The authors also tested whether doses of GABA or IVM and volatile anesthetics were additive in their effects on C. elegans. Halothane (2.1\%) did not shift the ED50 of IVM, but was antagonistic to GABA. Enflurane (4\%) was antagonistic to both IVM and GABA. However, ED50s of halothane and enflurane were unchanged in the presence of IVM (35 nM) or GABA (150 mM). The authors conclude that GABA by itself does not appear to mediate halothane or enflurane sensitivity in C. elegans.}, author = {Boswell, M. V. and Morgan, P. G. and Sedensky, M. M.}, citeulike-article-id = {3275667}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/2335273}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=2335273}, citeulike-linkout-2 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00001289}, journal = {FASEB Journal}, keywords = {ackn\_cgc, anesthetic, article, behav-movement, c\_elegans, caenorhabditis\_drug\_effects, caenorhabditis\_elegans, celegans, dose\_response\_relationship\_drug, drug\_resistance\_genetics, e03a36, elegans, enflurane\_pharmacology, gaba\_antagonists\_and\_inhibitors, gaba\_physiology, halothane\_pharmacology, inhib-anthelminthic, ivermectin\_pharmacology, motor\_activity\_drug\_effects, mut-drug\_sensitivity, mut-uncoordinated, mutation, nematode, r12h71, unc-79, unc-9, wormbase}, pages = {2506--2510}, posted-at = {2008-09-16 20:38:06}, priority = {3}, title = {Interaction of GABA and volatile anesthetics in the nematode Caenorhabditis elegans.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/2335273}, volume = {4}, year = {1990} }

TY - JOUR ID - citeulike:3275667 L3 - citeulike-article-id:3275667 N2 - The authors tested whether mutant strains of Caenorhabditis elegans with altered sensitivity to volatile anesthetics have altered responses to GABA or GABA-agonists. They determined the ED50s of the wild-type strain N2 and two mutant strains of C. elegans to a GABA-mimetic ivermectin (IVM) and to GABA. unc-79, a strain with increased sensitivity to halothane, was more sensitive than N2 to IVM and GABA. unc-9, a strain that suppresses the increased sensitivity of unc-79 to halothane, was less sensitive than N2 to IVM and GABA. The authors also tested whether doses of GABA or IVM and volatile anesthetics were additive in their effects on C. elegans. Halothane (2.1%) did not shift the ED50 of IVM, but was antagonistic to GABA. Enflurane (4%) was antagonistic to both IVM and GABA. However, ED50s of halothane and enflurane were unchanged in the presence of IVM (35 nM) or GABA (150 mM). The authors conclude that GABA by itself does not appear to mediate halothane or enflurane sensitivity in C. elegans. JF - FASEB Journal EP - 2510 TI - Interaction of GABA and volatile anesthetics in the nematode Caenorhabditis elegans. VL - 4 SP - 2506 KW - ackn_cgc KW - anesthetic KW - article KW - behav-movement KW - c_elegans KW - caenorhabditis_drug_effects KW - caenorhabditis_elegans KW - celegans KW - dose_response_relationship_drug KW - drug_resistance_genetics KW - e03a36 KW - elegans KW - enflurane_pharmacology KW - gaba_antagonists_and_inhibitors KW - gaba_physiology KW - halothane_pharmacology KW - inhib-anthelminthic KW - ivermectin_pharmacology KW - motor_activity_drug_effects KW - mut-drug_sensitivity KW - mut-uncoordinated KW - mutation KW - nematode KW - r12h71 KW - unc-79 KW - unc-9 KW - wormbase AU - Boswell, MV AU - Morgan, PG AU - Sedensky, MM PY - 1990/// UR - http://view.ncbi.nlm.nih.gov/pubmed/2335273 ER -