Multiple chemosensory defects in daf-11 and daf-21 mutants of Caenorhabditis elegans. Export

@article{citeulike:3276731, abstract = {Phenotypic analysis of the daf-11 and daf-21 mutants of Caenorhabditis elegans suggests that they have defects in components shared by processes analogous to vertebrate taste and olfaction. daf-11 and daf-21 mutations were previously shown to cause inappropriate response to the dauer-inducing pheromone. By mutational analysis and by disabling specific chemosensory sensilla with a laser, we show that neurons in the amphid sensilla are required for this pheromone response. Using behavioral assays, we find that daf-11 and daf-21 mutants are not defective in avoidance of certain non-volatile repellents, but are defective in taxis to non-volatile attractants. In addition, both mutants are defective in taxis to volatile attractants detected primarily by the amphid neuron AWC, but respond normally to volatile attractants detected primarily by AWA. We propose that daf-11 and daf-21 mediate sensory transduction for both volatile and non-volatile compounds in specific amphid neurons.}, author = {Vowels, J. J. and Thomas, J. H.}, citeulike-article-id = {3276731}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/7828815}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=7828815}, citeulike-linkout-2 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00002033}, journal = {Genetics}, keywords = {alleles, article, b02403, c47e85, c\_elegans, caenorhabditis\_elegans, caenorhabditis\_elegans\_genetics, caenorhabditis\_elegans\_physiology, celegans, chemotaxis\_genetics, daf-11, daf-21, dna\_mutational\_analysis, elegans, genes\_dominant, nematode, osmolar\_concentration, phenotype, pheromones\_physiology, smell, taste, vertebrates, wormbase}, pages = {303--316}, posted-at = {2008-09-16 23:45:24}, priority = {3}, title = {Multiple chemosensory defects in daf-11 and daf-21 mutants of Caenorhabditis elegans.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/7828815}, volume = {138}, year = {1994} }

TY - JOUR ID - citeulike:3276731 L3 - citeulike-article-id:3276731 N2 - Phenotypic analysis of the daf-11 and daf-21 mutants of Caenorhabditis elegans suggests that they have defects in components shared by processes analogous to vertebrate taste and olfaction. daf-11 and daf-21 mutations were previously shown to cause inappropriate response to the dauer-inducing pheromone. By mutational analysis and by disabling specific chemosensory sensilla with a laser, we show that neurons in the amphid sensilla are required for this pheromone response. Using behavioral assays, we find that daf-11 and daf-21 mutants are not defective in avoidance of certain non-volatile repellents, but are defective in taxis to non-volatile attractants. In addition, both mutants are defective in taxis to volatile attractants detected primarily by the amphid neuron AWC, but respond normally to volatile attractants detected primarily by AWA. We propose that daf-11 and daf-21 mediate sensory transduction for both volatile and non-volatile compounds in specific amphid neurons. JF - Genetics EP - 316 TI - Multiple chemosensory defects in daf-11 and daf-21 mutants of Caenorhabditis elegans. VL - 138 SP - 303 KW - alleles KW - article KW - b02403 KW - c47e85 KW - c_elegans KW - caenorhabditis_elegans KW - caenorhabditis_elegans_genetics KW - caenorhabditis_elegans_physiology KW - celegans KW - chemotaxis_genetics KW - daf-11 KW - daf-21 KW - dna_mutational_analysis KW - elegans KW - genes_dominant KW - nematode KW - osmolar_concentration KW - phenotype KW - pheromones_physiology KW - smell KW - taste KW - vertebrates KW - wormbase AU - Vowels, JJ AU - Thomas, JH PY - 1994/// UR - http://view.ncbi.nlm.nih.gov/pubmed/7828815 ER -