gld-1, a tumor suppressor gene required for oocyte development in Caenorhabditis elegans. Export

@article{citeulike:3276826, abstract = {We have characterized 31 mutations in the gld-1 (defective in germline development) gene of Caenorhabditis elegans. In gld-1 (null) hermaphrodites, oogenesis is abolished and a germline tumor forms where oocyte development would normally occur. By contrast, gld-1 (null) males are unaffected. The hermaphrodite germline tumor appears to derive from germ cells that enter the meiotic pathway normally but then exit pachytene and return to the mitotic cycle. Certain gld-1 partial loss-of-function mutations also abolish oogenesis, but germ cells arrest in pachytene rather than returning to mitosis. Our results indicate that gld-1 is a tumor suppressor gene required for oocyte development. The tumorous phenotype suggests that gld-1(+) may function to negatively regulate proliferation during meiotic prophase and/or act to direct progression through meiotic prophase. We also show that gld-1(+) has an additional nonessential role in germline sex determination: promotion of hermaphrodite spermatogenesis. This function of gld-1 is inferred from a haplo-insufficient phenotype and from the properties of gain-of-function gld-1 mutations that cause alterations in the sexual identity of germ}, author = {Francis, R. and Barton, M. K. and Kimble, J. E. and Schedl, T. B.}, citeulike-article-id = {3276826}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/7713419}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=7713419}, citeulike-linkout-2 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00002113}, journal = {Genetics}, keywords = {article, c\_elegans, caenorhabditis\_elegans, celegans, elegans, genes\_dominant\_genetics, genes\_helminth\_genetics, genes\_helminth\_physiology, genes\_suppressor\_tumor\_genetics, genes\_suppressor\_tumor\_physiology, genetic\_complementation\_test, germ\_cells\_physiology, germinoma, gld-1, hermaphroditism, meiosis, mitosis, mutation\_physiology, nematode, oogenesis\_genetics, phenotype, sex\_differentiation\_genetics, spermatogenesis\_genetics, t23g113, wormbase}, pages = {579--606}, posted-at = {2008-09-17 00:02:17}, priority = {3}, title = {gld-1, a tumor suppressor gene required for oocyte development in Caenorhabditis elegans.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/7713419}, volume = {139}, year = {1995} }

TY - JOUR ID - citeulike:3276826 L3 - citeulike-article-id:3276826 N2 - We have characterized 31 mutations in the gld-1 (defective in germline development) gene of Caenorhabditis elegans. In gld-1 (null) hermaphrodites, oogenesis is abolished and a germline tumor forms where oocyte development would normally occur. By contrast, gld-1 (null) males are unaffected. The hermaphrodite germline tumor appears to derive from germ cells that enter the meiotic pathway normally but then exit pachytene and return to the mitotic cycle. Certain gld-1 partial loss-of-function mutations also abolish oogenesis, but germ cells arrest in pachytene rather than returning to mitosis. Our results indicate that gld-1 is a tumor suppressor gene required for oocyte development. The tumorous phenotype suggests that gld-1(+) may function to negatively regulate proliferation during meiotic prophase and/or act to direct progression through meiotic prophase. We also show that gld-1(+) has an additional nonessential role in germline sex determination: promotion of hermaphrodite spermatogenesis. This function of gld-1 is inferred from a haplo-insufficient phenotype and from the properties of gain-of-function gld-1 mutations that cause alterations in the sexual identity of germ JF - Genetics EP - 606 TI - gld-1, a tumor suppressor gene required for oocyte development in Caenorhabditis elegans. VL - 139 SP - 579 KW - article KW - c_elegans KW - caenorhabditis_elegans KW - celegans KW - elegans KW - genes_dominant_genetics KW - genes_helminth_genetics KW - genes_helminth_physiology KW - genes_suppressor_tumor_genetics KW - genes_suppressor_tumor_physiology KW - genetic_complementation_test KW - germ_cells_physiology KW - germinoma KW - gld-1 KW - hermaphroditism KW - meiosis KW - mitosis KW - mutation_physiology KW - nematode KW - oogenesis_genetics KW - phenotype KW - sex_differentiation_genetics KW - spermatogenesis_genetics KW - t23g113 KW - wormbase AU - Francis, R AU - Barton, MK AU - Kimble, JE AU - Schedl, TB PY - 1995/// UR - http://view.ncbi.nlm.nih.gov/pubmed/7713419 ER -