Mechanosensory signalling in C. elegans mediated by the GLR-1 glutamate receptor. Export

@article{citeulike:3277179, abstract = {Neuronal signalling across synapses involves activation of many neurotransmitter receptors on postsynaptic cells. glr-1 encodes a potential glutamate receptor in the nematode Caenorhabditis elegans which is most similar to vertebrate AMPA-type ionotropic glutamate receptors(1). glr-1 is expressed in motor neurons and interneurons, including interneurons implicated in the control of locomotion(2). Here we investigate the contribution of glr-1 to the normal signalling of these neurons, by generating a deletion mutation in glr-1. We find that mutant worms are deficient in their ability to withdraw backwards when mechanically stimulated, but they withdraw normally in response to chemical repellents. The ASH sensory neurons mediate withdrawal responses both to mechanical stimuli and to chemical repellents(3,4), and ASH makes chemical synapses with glr-1-expressing interneurons. Our results suggest that postsynaptic interneurons use different neurotransmitter receptors to process two sensory stimuli detected by one sensory neuron.}, author = {Maricq, A. V. and Peckol, E. L. and Driscoll, M. A. and Bargmann, C. I.}, citeulike-article-id = {3277179}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/7477293}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=7477293}, citeulike-linkout-2 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00002308}, journal = {Nature}, keywords = {amino\_acid\_sequence, animals\_transgenic, article, base\_sequence, c06e14, c\_elegans, caenorhabditis\_elegans, caenorhabditis\_elegans\_genetics, caenorhabditis\_elegans\_metabolism, celegans, dna\_primers, elegans, glr-1, interneurons\_metabolism, mec-4, membrane\_proteins\_genetics, membrane\_proteins\_metabolism, molecular\_sequence\_data, motor\_neurons\_metabolism, mutagenesis\_insertional, nematode, nerve\_tissue\_proteins\_genetics, nerve\_tissue\_proteins\_metabolism, neurons\_metabolism, polymerase\_chain\_reaction, receptors\_glutamate\_genetics, receptors\_glutamate\_metabolism, sequence\_deletion, signal\_transduction, synapses\_physiology, t01c87, wormbase}, pages = {78--81}, posted-at = {2008-09-17 00:52:30}, priority = {3}, title = {Mechanosensory signalling in C. elegans mediated by the GLR-1 glutamate receptor.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/7477293}, volume = {378}, year = {1995} }

TY - JOUR ID - citeulike:3277179 L3 - citeulike-article-id:3277179 N2 - Neuronal signalling across synapses involves activation of many neurotransmitter receptors on postsynaptic cells. glr-1 encodes a potential glutamate receptor in the nematode Caenorhabditis elegans which is most similar to vertebrate AMPA-type ionotropic glutamate receptors(1). glr-1 is expressed in motor neurons and interneurons, including interneurons implicated in the control of locomotion(2). Here we investigate the contribution of glr-1 to the normal signalling of these neurons, by generating a deletion mutation in glr-1. We find that mutant worms are deficient in their ability to withdraw backwards when mechanically stimulated, but they withdraw normally in response to chemical repellents. The ASH sensory neurons mediate withdrawal responses both to mechanical stimuli and to chemical repellents(3,4), and ASH makes chemical synapses with glr-1-expressing interneurons. Our results suggest that postsynaptic interneurons use different neurotransmitter receptors to process two sensory stimuli detected by one sensory neuron. JF - Nature EP - 81 TI - Mechanosensory signalling in C. elegans mediated by the GLR-1 glutamate receptor. VL - 378 SP - 78 KW - amino_acid_sequence KW - animals_transgenic KW - article KW - base_sequence KW - c06e14 KW - c_elegans KW - caenorhabditis_elegans KW - caenorhabditis_elegans_genetics KW - caenorhabditis_elegans_metabolism KW - celegans KW - dna_primers KW - elegans KW - glr-1 KW - interneurons_metabolism KW - mec-4 KW - membrane_proteins_genetics KW - membrane_proteins_metabolism KW - molecular_sequence_data KW - motor_neurons_metabolism KW - mutagenesis_insertional KW - nematode KW - nerve_tissue_proteins_genetics KW - nerve_tissue_proteins_metabolism KW - neurons_metabolism KW - polymerase_chain_reaction KW - receptors_glutamate_genetics KW - receptors_glutamate_metabolism KW - sequence_deletion KW - signal_transduction KW - synapses_physiology KW - t01c87 KW - wormbase AU - Maricq, AV AU - Peckol, EL AU - Driscoll, MA AU - Bargmann, CI PY - 1995/// UR - http://view.ncbi.nlm.nih.gov/pubmed/7477293 ER -