Correct Hox gene expression established independently of position in Caenorhabditis elegans. Export

@article{citeulike:3278474, abstract = {The Hox genes are expressed in a conserved sequence of spatial domains along the anteroposterior (A/P) body axes of many organisms. In Drosophila, position-specific signals located along the A/P axis establish the pattern of Hox gene expression. In the nematode Caenorhabditis elegans, it is not known how the pattern of Hox gene expression is established. C. elegans uses lineal control mechanisms and local cell interactions to specify early blastomere identities. However, many cells expressing the same Hox gene are unrelated by lineage, suggesting that, as in Drosophila, domains of Hox gene expression may be defined by cell-extrinsic A/P positional signals. To test this, we have investigated whether posterior mesodermal and ectodermal cells will express their normal posterior Hox gene when they are mispositioned in the anterior. Surprisingly, we find that correct Hox gene expression does not depend on cell position, but is highly correlated with cell lineage. Thus, although the most striking feature of Hox gene expression is its positional specificity, in C. elegans the pattern is achieved, at least in part, by a lineage-specific control system that operates without regard to A/P position.AD - Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143-0554, USA.FAU - Cowing, DAU - Cowing DFAU - Kenyon, CAU - Kenyon CLA - engPT - Journal ArticleCY - ENGLANDTA - NatureJID - 0410462RN - 0 (Helminth Proteins)RN - 0 (Homeodomain Proteins)RN - 0 (Mab-5 protein)RN - 0 (Transcription Factors)SB - IM}, author = {Cowing, D. W. and Kenyon, C. J.}, citeulike-article-id = {3278474}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/8684464}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=8684464}, citeulike-linkout-2 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00002503}, journal = {Nature}, keywords = {article, c08c33, c\_elegans, caenorhabditis\_elegans, caenorhabditis\_embryology, caenorhabditis\_genetics, celegans, cell\_differentiation, cell\_movement, ectoderm\_cytology, ectoderm\_metabolism, elegans, gene\_expression\_regulation\_developmental, genes\_homeobox, helminth\_proteins\_biosynthesis, helminth\_proteins\_genetics, homeodomain\_proteins\_biosynthesis, homeodomain\_proteins\_genetics, mab-5, mesoderm\_cytology, mesoderm\_metabolism, nematode, signal\_transduction, transcription\_factors\_biosynthesis, transcription\_factors\_genetics, wormbase}, pages = {353--356}, posted-at = {2008-09-17 01:50:47}, priority = {3}, title = {Correct Hox gene expression established independently of position in Caenorhabditis elegans.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/8684464}, volume = {382}, year = {1996} }

TY - JOUR ID - citeulike:3278474 L3 - citeulike-article-id:3278474 N2 - The Hox genes are expressed in a conserved sequence of spatial domains along the anteroposterior (A/P) body axes of many organisms. In Drosophila, position-specific signals located along the A/P axis establish the pattern of Hox gene expression. In the nematode Caenorhabditis elegans, it is not known how the pattern of Hox gene expression is established. C. elegans uses lineal control mechanisms and local cell interactions to specify early blastomere identities. However, many cells expressing the same Hox gene are unrelated by lineage, suggesting that, as in Drosophila, domains of Hox gene expression may be defined by cell-extrinsic A/P positional signals. To test this, we have investigated whether posterior mesodermal and ectodermal cells will express their normal posterior Hox gene when they are mispositioned in the anterior. Surprisingly, we find that correct Hox gene expression does not depend on cell position, but is highly correlated with cell lineage. Thus, although the most striking feature of Hox gene expression is its positional specificity, in C. elegans the pattern is achieved, at least in part, by a lineage-specific control system that operates without regard to A/P position.AD - Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143-0554, USA.FAU - Cowing, DAU - Cowing DFAU - Kenyon, CAU - Kenyon CLA - engPT - Journal ArticleCY - ENGLANDTA - NatureJID - 0410462RN - 0 (Helminth Proteins)RN - 0 (Homeodomain Proteins)RN - 0 (Mab-5 protein)RN - 0 (Transcription Factors)SB - IM JF - Nature EP - 356 TI - Correct Hox gene expression established independently of position in Caenorhabditis elegans. VL - 382 SP - 353 KW - article KW - c08c33 KW - c_elegans KW - caenorhabditis_elegans KW - caenorhabditis_embryology KW - caenorhabditis_genetics KW - celegans KW - cell_differentiation KW - cell_movement KW - ectoderm_cytology KW - ectoderm_metabolism KW - elegans KW - gene_expression_regulation_developmental KW - genes_homeobox KW - helminth_proteins_biosynthesis KW - helminth_proteins_genetics KW - homeodomain_proteins_biosynthesis KW - homeodomain_proteins_genetics KW - mab-5 KW - mesoderm_cytology KW - mesoderm_metabolism KW - nematode KW - signal_transduction KW - transcription_factors_biosynthesis KW - transcription_factors_genetics KW - wormbase AU - Cowing, DW AU - Kenyon, CJ PY - 1996/// UR - http://view.ncbi.nlm.nih.gov/pubmed/8684464 ER -