Identification of a zinc finger encoding gene in Onchocerca volvulus. Export

@article{citeulike:3290650, abstract = {Eukaryotic transcription factors can be identified and classified according to conserved DNA-binding motifs and conserved regulatory domains. The functional and structural analysis, and the conservation of these genes among metazoans emphasizes the importance of these DNA-binding proteins in development and differentiation. In order to identify genes with common DNA-binding motifs in the genome of Onchocerca volvulus we have cloned a zinc finger encoding gene of the structure C2-H2. Using the Caenorhabditis elegans sex determining tra-1 gene as a probe we have identified two tra-1 related genes in the genome of O. volvulus. The zinc finger region of one of these genes (OvZf1) was subcloned sequenced. The predicted protein has at least eight consecutive zinc fingers and each finger possesses the characteristic paired cysteine- and histidine residues and the proper spacing of the amino acids between the conserved residues.}, author = {Holst, C. and Zipfel, P. F.}, citeulike-article-id = {3290650}, citeulike-linkout-0 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00012046}, journal = {Tropical Medicine and Parasitology}, keywords = {amino\_acid\_sequence, article, base\_sequence, blotting\_southern, c\_elegans, caenorhabditis\_elegans, celegans, cloning\_molecular, dna\_analysis, dna\_binding\_proteins\_chemistry, dna\_binding\_proteins\_genetics, dna\_chemistry, elegans, genes\_helminth, genes\_reiterated, molecular\_sequence\_data, nematode, onchocerca\_volvulus\_genetics, repetitive\_sequences\_nucleic\_acid, sequence\_alignment, sequence\_analysis\_dna, tra-1, transcription\_factors\_genetics, wormbase, y47d3a6, zinc\_fingers\_genetics}, pages = {147--151}, posted-at = {2008-09-18 21:44:57}, priority = {3}, title = {Identification of a zinc finger encoding gene in Onchocerca volvulus.}, url = {http://www.wormbase.org/db/misc/paper?name=WBPaper00012046}, volume = {44}, year = {1993} }

TY - JOUR ID - citeulike:3290650 L3 - citeulike-article-id:3290650 N2 - Eukaryotic transcription factors can be identified and classified according to conserved DNA-binding motifs and conserved regulatory domains. The functional and structural analysis, and the conservation of these genes among metazoans emphasizes the importance of these DNA-binding proteins in development and differentiation. In order to identify genes with common DNA-binding motifs in the genome of Onchocerca volvulus we have cloned a zinc finger encoding gene of the structure C2-H2. Using the Caenorhabditis elegans sex determining tra-1 gene as a probe we have identified two tra-1 related genes in the genome of O. volvulus. The zinc finger region of one of these genes (OvZf1) was subcloned sequenced. The predicted protein has at least eight consecutive zinc fingers and each finger possesses the characteristic paired cysteine- and histidine residues and the proper spacing of the amino acids between the conserved residues. JF - Tropical Medicine and Parasitology EP - 151 TI - Identification of a zinc finger encoding gene in Onchocerca volvulus. VL - 44 SP - 147 KW - amino_acid_sequence KW - article KW - base_sequence KW - blotting_southern KW - c_elegans KW - caenorhabditis_elegans KW - celegans KW - cloning_molecular KW - dna_analysis KW - dna_binding_proteins_chemistry KW - dna_binding_proteins_genetics KW - dna_chemistry KW - elegans KW - genes_helminth KW - genes_reiterated KW - molecular_sequence_data KW - nematode KW - onchocerca_volvulus_genetics KW - repetitive_sequences_nucleic_acid KW - sequence_alignment KW - sequence_analysis_dna KW - tra-1 KW - transcription_factors_genetics KW - wormbase KW - y47d3a6 KW - zinc_fingers_genetics AU - Holst, C AU - Zipfel, PF PY - 1993/// UR - http://www.wormbase.org/db/misc/paper?name=WBPaper00012046 ER -