DNA-binding properties and secondary structural model of the hepatocyte nuclear factor 3/fork head domain. Export

@article{citeulike:3290653, abstract = {An 84-amino acid segment of QRF-1 [glutamine (Q)-rich factor 1], a newly cloned, B-cell-derived DNA-binding protein, shows significant sequence homology with the DNA-binding domains of the hepatocyte nuclear factor 3/fork head family of proteins. Here we demonstrate that this 84-amino acid domain is necessary and sufficient for DNA binding. We also propose a secondary structural model for the domain. At the N-terminal portion of the model, a basic hook structure is followed by two amphipathic helices separated by a turn. Invariant amino acid residues within the two proposed helices form the hydrophobic cores. An aromatic kink and a third amphipathic helix comprise the center of the domain. At the C terminus, two variable-length loops flank a putative 7-amino acid helix followed by a short basic region.}, author = {Li, C. and Tucker, P. W.}, citeulike-article-id = {3290653}, citeulike-linkout-0 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00012052}, journal = {Proceedings of the National Academy of Sciences USA}, keywords = {amino\_acid\_sequence, article, base\_sequence, binding\_sites, c\_elegans, caenorhabditis\_elegans, caenorhabditis\_elegans\_metabolism, celegans, cloning\_molecular, consensus\_sequence, conserved\_sequence, dna\_binding\_proteins\_chemistry, dna\_binding\_proteins\_metabolism, drosophila\_metabolism, elegans, mice, molecular\_sequence\_data, nematode, nuclear\_proteins\_chemistry, nuclear\_proteins\_metabolism, oligodeoxyribonucleotides\_chemical\_synthesis, oligodeoxyribonucleotides\_metabolism, polymerase\_chain\_reaction, protein\_structure\_secondary, rats, recombinant\_fusion\_proteins\_biosynthesis, recombinant\_proteins\_chemistry, recombinant\_proteins\_metabolism, saccharomyces\_cerevisiae\_metabolism, sequence\_homology\_amino\_acid, transcription\_factors\_chemistry, transcription\_factors\_metabolism, wormbase, xenopus}, pages = {11583--11587}, posted-at = {2008-09-18 21:45:37}, priority = {3}, title = {DNA-binding properties and secondary structural model of the hepatocyte nuclear factor 3/fork head domain.}, url = {http://www.wormbase.org/db/misc/paper?name=WBPaper00012052}, volume = {90}, year = {1993} }

TY - JOUR ID - citeulike:3290653 L3 - citeulike-article-id:3290653 N2 - An 84-amino acid segment of QRF-1 [glutamine (Q)-rich factor 1], a newly cloned, B-cell-derived DNA-binding protein, shows significant sequence homology with the DNA-binding domains of the hepatocyte nuclear factor 3/fork head family of proteins. Here we demonstrate that this 84-amino acid domain is necessary and sufficient for DNA binding. We also propose a secondary structural model for the domain. At the N-terminal portion of the model, a basic hook structure is followed by two amphipathic helices separated by a turn. Invariant amino acid residues within the two proposed helices form the hydrophobic cores. An aromatic kink and a third amphipathic helix comprise the center of the domain. At the C terminus, two variable-length loops flank a putative 7-amino acid helix followed by a short basic region. JF - Proceedings of the National Academy of Sciences USA EP - 11587 TI - DNA-binding properties and secondary structural model of the hepatocyte nuclear factor 3/fork head domain. VL - 90 SP - 11583 KW - amino_acid_sequence KW - article KW - base_sequence KW - binding_sites KW - c_elegans KW - caenorhabditis_elegans KW - caenorhabditis_elegans_metabolism KW - celegans KW - cloning_molecular KW - consensus_sequence KW - conserved_sequence KW - dna_binding_proteins_chemistry KW - dna_binding_proteins_metabolism KW - drosophila_metabolism KW - elegans KW - mice KW - molecular_sequence_data KW - nematode KW - nuclear_proteins_chemistry KW - nuclear_proteins_metabolism KW - oligodeoxyribonucleotides_chemical_synthesis KW - oligodeoxyribonucleotides_metabolism KW - polymerase_chain_reaction KW - protein_structure_secondary KW - rats KW - recombinant_fusion_proteins_biosynthesis KW - recombinant_proteins_chemistry KW - recombinant_proteins_metabolism KW - saccharomyces_cerevisiae_metabolism KW - sequence_homology_amino_acid KW - transcription_factors_chemistry KW - transcription_factors_metabolism KW - wormbase KW - xenopus AU - Li, C AU - Tucker, PW PY - 1993/// UR - http://www.wormbase.org/db/misc/paper?name=WBPaper00012052 ER -