Ancient conserved regions in new gene sequences and the protein databases. Export

@article{citeulike:3290797, abstract = {Sets of new gene sequences from human, nematode, and yeast were compared with each other and with a set of Escherichia coli genes in order to detect ancient evolutionarily conserved regions (ACRs) in the encoded proteins. Nearly all of the ACRs so identified were found to be homologous to sequences in the protein databases. This suggests that currently known proteins may already include representatives of most ACRs and that new sequences not similar to any database sequence are unlikely to contain ACRs. Preliminary analyses indicate that moderately expressed genes may be more likely to contain ACRs than rarely expressed genes. It is estimated that there are fewer than 900 ACRs in all.}, author = {Green, P. and Lipman, D. and Hillier, L. and Waterston, R. H. and States, D. J. and Claverie, J. M.}, citeulike-article-id = {3290797}, citeulike-linkout-0 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00012284}, journal = {Science}, keywords = {amino\_acid\_sequence, article, base\_sequence, c\_elegans, caenorhabditis\_elegans, caenorhabditis\_elegans\_genetics, celegans, conserved\_sequence, databases\_factual, elegans, escherichia\_coli\_genetics, evolution, molecular\_sequence\_data, nematode, proteins\_chemistry, proteins\_genetics, saccharomyces\_cerevisiae\_genetics, sequence\_homology, software, wormbase}, pages = {1711--1716}, posted-at = {2008-09-18 22:18:38}, priority = {3}, title = {Ancient conserved regions in new gene sequences and the protein databases.}, url = {http://www.wormbase.org/db/misc/paper?name=WBPaper00012284}, volume = {259}, year = {1993} }

TY - JOUR ID - citeulike:3290797 L3 - citeulike-article-id:3290797 N2 - Sets of new gene sequences from human, nematode, and yeast were compared with each other and with a set of Escherichia coli genes in order to detect ancient evolutionarily conserved regions (ACRs) in the encoded proteins. Nearly all of the ACRs so identified were found to be homologous to sequences in the protein databases. This suggests that currently known proteins may already include representatives of most ACRs and that new sequences not similar to any database sequence are unlikely to contain ACRs. Preliminary analyses indicate that moderately expressed genes may be more likely to contain ACRs than rarely expressed genes. It is estimated that there are fewer than 900 ACRs in all. JF - Science EP - 1716 TI - Ancient conserved regions in new gene sequences and the protein databases. VL - 259 SP - 1711 KW - amino_acid_sequence KW - article KW - base_sequence KW - c_elegans KW - caenorhabditis_elegans KW - caenorhabditis_elegans_genetics KW - celegans KW - conserved_sequence KW - databases_factual KW - elegans KW - escherichia_coli_genetics KW - evolution KW - molecular_sequence_data KW - nematode KW - proteins_chemistry KW - proteins_genetics KW - saccharomyces_cerevisiae_genetics KW - sequence_homology KW - software KW - wormbase AU - Green, P AU - Lipman, D AU - Hillier, L AU - Waterston, RH AU - States, DJ AU - Claverie, JM PY - 1993/// UR - http://www.wormbase.org/db/misc/paper?name=WBPaper00012284 ER -