Transcription factor NFY globally represses the expression of the C. elegans Hox gene Abdominal-B homolog egl-5. Export

@article{citeulike:3334065, abstract = {The C. elegans Hox gene egl-5 (ortholog of Drosophila Abdominal-B) is expressed in multiple tissues in the tail region and is involved in tail patterning. In this study, we identify and clone the corresponding C. elegans orthologs of the components of the heterotrimeric transcription factor NFY, nfya-1, nfyb-1 and nfyc-1 and demonstrate that mutations in these components result in the ectopic expression of egl-5 outside of its normal expression domains. The NFYA-1 protein forms a complex with NFYB-1 and NFYC-1, specifically recognizing the CCAAT box. Mutating a CCAAT box in the proximal promoter of egl-5 also leads to the derepression of egl-5, suggesting a direct role for the NFY complex in the regulation of egl-5. In addition, we show that the NFY complex interacts with the MES-2/MES-6 PcG complex in Hox gene regulation. Thus, our studies unravel a physiological function of NFY in establishing the spatially restricted expression pattern of egl-5.}, author = {Deng, H. and Sun, Y. and Zhang, Y. and Luo, X. and Hou, W. and Yan, L. and Chen, Y. and Tian, E. and Han, J. and Zhang, H.}, citeulike-article-id = {3334065}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/17574230}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=17574230}, citeulike-linkout-2 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00030771}, journal = {Dev Biol}, keywords = {c08c31, c09g45, c\_elegans, caenorhabditis\_elegans, celegans, egl-5, elegans, f23f11, f54c13, mes-2, mes-3, mes-4, mes-6, nematode, nfya-1, nfya-2, nfyb-1, nfyc-1, other, r06a47, t08d101, w10d94, wormbase, y2h9a1, y53h1a5}, pages = {583--592}, posted-at = {2008-09-24 22:44:08}, priority = {3}, title = {Transcription factor NFY globally represses the expression of the C. elegans Hox gene Abdominal-B homolog egl-5.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/17574230}, volume = {308}, year = {2007} }

TY - JOUR ID - citeulike:3334065 L3 - citeulike-article-id:3334065 N2 - The C. elegans Hox gene egl-5 (ortholog of Drosophila Abdominal-B) is expressed in multiple tissues in the tail region and is involved in tail patterning. In this study, we identify and clone the corresponding C. elegans orthologs of the components of the heterotrimeric transcription factor NFY, nfya-1, nfyb-1 and nfyc-1 and demonstrate that mutations in these components result in the ectopic expression of egl-5 outside of its normal expression domains. The NFYA-1 protein forms a complex with NFYB-1 and NFYC-1, specifically recognizing the CCAAT box. Mutating a CCAAT box in the proximal promoter of egl-5 also leads to the derepression of egl-5, suggesting a direct role for the NFY complex in the regulation of egl-5. In addition, we show that the NFY complex interacts with the MES-2/MES-6 PcG complex in Hox gene regulation. Thus, our studies unravel a physiological function of NFY in establishing the spatially restricted expression pattern of egl-5. JF - Dev Biol EP - 592 TI - Transcription factor NFY globally represses the expression of the C. elegans Hox gene Abdominal-B homolog egl-5. VL - 308 SP - 583 KW - c08c31 KW - c09g45 KW - c_elegans KW - caenorhabditis_elegans KW - celegans KW - egl-5 KW - elegans KW - f23f11 KW - f54c13 KW - mes-2 KW - mes-3 KW - mes-4 KW - mes-6 KW - nematode KW - nfya-1 KW - nfya-2 KW - nfyb-1 KW - nfyc-1 KW - other KW - r06a47 KW - t08d101 KW - w10d94 KW - wormbase KW - y2h9a1 KW - y53h1a5 AU - Deng, H AU - Sun, Y AU - Zhang, Y AU - Luo, X AU - Hou, W AU - Yan, L AU - Chen, Y AU - Tian, E AU - Han, J AU - Zhang, H PY - 2007/// UR - http://view.ncbi.nlm.nih.gov/pubmed/17574230 ER -