MEG-1 and MEG-2 Are Embryo-Specific P-Granule Components Required for Germline Development in Caenorhabditis elegans. Export

@article{citeulike:3336559, abstract = {In Caenorhabditis elegans, germ granules called P granules are directly inherited from mother to daughter and segregate with the germ lineage as it separates from the soma during initial embryonic cell divisions. Here we define meg-1 and meg-2 (maternal-effect germ-cell defective), which are expressed in the maternal germline and encode proteins that localize exclusively to P granules during embryonic germline segregation. Localization of MEG-1 to P granules depends upon the membrane-bound protein MES-1. meg-1 mutants exhibit multiple germline defects: P-granule mis-segregation in embryos, underproliferation and aberrant P-granule morphology in larval germ cells, and ultimately, sterility as adults. The penetrance of meg-1 phenotypes increases when meg-2 is also absent. Loss of the P-granule component pgl-1 in meg-1 mutants increases germ-cell proliferation, while loss of glh-1 decreases proliferation. Because meg-1 is provided maternally but its action is required in the embryonic germ lineage during segregation from somatic lineages, it provides a critical link for ensuring the continuity of germline development from one generation to the next.}, author = {Leacock, S. W. and Reinke, V.}, citeulike-article-id = {3336559}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/18202375}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=18202375}, citeulike-linkout-2 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00031440}, journal = {Genetics}, keywords = {article, c35d109, c\_elegans, caenorhabditis\_elegans, ced-4, celegans, elegans, f54f75, glh-1, k02b91, k02b92, meg-1, meg-2, mes-1, nematode, nos-2, pgl-1, t21g53, wormbase, zk11271, zk3814}, pages = {295--306}, posted-at = {2008-09-25 15:52:00}, priority = {3}, title = {MEG-1 and MEG-2 Are Embryo-Specific P-Granule Components Required for Germline Development in Caenorhabditis elegans.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18202375}, volume = {178}, year = {2008} }

TY - JOUR ID - citeulike:3336559 L3 - citeulike-article-id:3336559 N2 - In Caenorhabditis elegans, germ granules called P granules are directly inherited from mother to daughter and segregate with the germ lineage as it separates from the soma during initial embryonic cell divisions. Here we define meg-1 and meg-2 (maternal-effect germ-cell defective), which are expressed in the maternal germline and encode proteins that localize exclusively to P granules during embryonic germline segregation. Localization of MEG-1 to P granules depends upon the membrane-bound protein MES-1. meg-1 mutants exhibit multiple germline defects: P-granule mis-segregation in embryos, underproliferation and aberrant P-granule morphology in larval germ cells, and ultimately, sterility as adults. The penetrance of meg-1 phenotypes increases when meg-2 is also absent. Loss of the P-granule component pgl-1 in meg-1 mutants increases germ-cell proliferation, while loss of glh-1 decreases proliferation. Because meg-1 is provided maternally but its action is required in the embryonic germ lineage during segregation from somatic lineages, it provides a critical link for ensuring the continuity of germline development from one generation to the next. JF - Genetics EP - 306 TI - MEG-1 and MEG-2 Are Embryo-Specific P-Granule Components Required for Germline Development in Caenorhabditis elegans. VL - 178 SP - 295 KW - article KW - c35d109 KW - c_elegans KW - caenorhabditis_elegans KW - ced-4 KW - celegans KW - elegans KW - f54f75 KW - glh-1 KW - k02b91 KW - k02b92 KW - meg-1 KW - meg-2 KW - mes-1 KW - nematode KW - nos-2 KW - pgl-1 KW - t21g53 KW - wormbase KW - zk11271 KW - zk3814 AU - Leacock, SW AU - Reinke, V PY - 2008/// UR - http://view.ncbi.nlm.nih.gov/pubmed/18202375 ER -