Memory in Caenorhabditis elegans Is Mediated by NMDA-Type Ionotropic Glutamate Receptors. Export

@article{citeulike:3337769, abstract = {Learning and memory are essential processes of both vertebrate and invertebrate nervous systems that allow animals to survive and reproduce. The neurotransmitter glutamate signals via ionotropic glutamate receptors (iGluRs) that have been linked to learning and memory formation [1, 2]; however, the signaling pathways that contribute to these behaviors are still not well understood. We therefore undertook a genetic and electrophysiological analysis of learning and memory in the nematode Caenorhabditis elegans. Here, we show that two genes, nmr-1 and nmr-2, are predicted to encode the subunits of an NMDA-type (NMDAR) iGluR that is necessary for memory retention in C. elegans. We cloned nmr-2, generated a deletion mutation in the gene, and showed that like nmr-1[3], nmr-2 is required for in vivo NMDA-gated currents. Using an associative-learning paradigm that pairs starvation with the attractant NaCl [4], we also showed that the memory of a learned avoidance response is dependent on NMR-1 and NMR-2 and that expression of NMDARs in a single pair of interneurons is sufficient for normal memory. Our results provide new insights into the molecular and cellular mechanisms underlying the memory of a learned event.}, author = {Kano, T. and Brockie, P. J. and Sassa, T. and Fujimoto, H. and Kawahara, Y. and Iino, Y. and Mellem, J. E. and Madsen, D. M. and Hosono, R. and Maricq, A. V.}, citeulike-article-id = {3337769}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.cub.2008.05.051}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18583134}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18583134}, citeulike-linkout-3 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00031974}, doi = {10.1016/j.cub.2008.05.051}, journal = {Curr Biol}, keywords = {b028012, c06e14, c\_elegans, caenorhabditis\_elegans, celegans, elegans, f07f66, glr-1, glr-2, k01c83, nematode, nmr-1, nmr-2, other, t01c310, tdc-1, wormbase}, posted-at = {2008-09-25 18:13:51}, priority = {3}, title = {Memory in Caenorhabditis elegans Is Mediated by NMDA-Type Ionotropic Glutamate Receptors.}, url = {http://dx.doi.org/10.1016/j.cub.2008.05.051}, year = {2008} }

TY - JOUR ID - citeulike:3337769 L3 - citeulike-article-id:3337769 N2 - Learning and memory are essential processes of both vertebrate and invertebrate nervous systems that allow animals to survive and reproduce. The neurotransmitter glutamate signals via ionotropic glutamate receptors (iGluRs) that have been linked to learning and memory formation [1, 2]; however, the signaling pathways that contribute to these behaviors are still not well understood. We therefore undertook a genetic and electrophysiological analysis of learning and memory in the nematode Caenorhabditis elegans. Here, we show that two genes, nmr-1 and nmr-2, are predicted to encode the subunits of an NMDA-type (NMDAR) iGluR that is necessary for memory retention in C. elegans. We cloned nmr-2, generated a deletion mutation in the gene, and showed that like nmr-1[3], nmr-2 is required for in vivo NMDA-gated currents. Using an associative-learning paradigm that pairs starvation with the attractant NaCl [4], we also showed that the memory of a learned avoidance response is dependent on NMR-1 and NMR-2 and that expression of NMDARs in a single pair of interneurons is sufficient for normal memory. Our results provide new insights into the molecular and cellular mechanisms underlying the memory of a learned event. JF - Curr Biol TI - Memory in Caenorhabditis elegans Is Mediated by NMDA-Type Ionotropic Glutamate Receptors. KW - b028012 KW - c06e14 KW - c_elegans KW - caenorhabditis_elegans KW - celegans KW - elegans KW - f07f66 KW - glr-1 KW - glr-2 KW - k01c83 KW - nematode KW - nmr-1 KW - nmr-2 KW - other KW - t01c310 KW - tdc-1 KW - wormbase AU - Kano, T AU - Brockie, PJ AU - Sassa, T AU - Fujimoto, H AU - Kawahara, Y AU - Iino, Y AU - Mellem, JE AU - Madsen, DM AU - Hosono, R AU - Maricq, AV PY - 2008/// UR - http://dx.doi.org/10.1016/j.cub.2008.05.051 ER -