Notch signalling is required for both dauer maintenance and recovery in C. elegans. Export

@article{citeulike:3337803, abstract = {The Notch signalling pathway is conserved among higher metazoans and is used repeatedly throughout development to specify distinct cell fates among populations of equipotent cells. Mounting evidence suggests that Notch signalling may also be crucial in neuronal function in postmitotic, differentiated neurons. Here, we demonstrate a novel role for the canonical Notch signalling pathway in postmitotic neurons during a specialised ''diapause-like'' post-embryonic developmental stage in C. elegans called dauer. Our data suggest that cell signalling downstream of the developmental decision to enter dauer leads to the activation of Notch-responding genes in postmitotic neurons. Consistent with this, we demonstrate that glp-1, one of the two C. elegans Notch receptors, and its ligand lag-2 are expressed in neurons during the dauer stage, and both genes are required to maintain this stage in a daf-7/TGFbeta dauer constitutive background. Our genetic data also suggest that a second Notch receptor, lin-12, functions upstream of, or in parallel with, insulin-like signalling components in response to replete growth conditions to promote dauer recovery. Based on our findings, cues associated with the onset of dauer ultimately trigger a glp-1-dependent Notch signalling cascade in neurons to maintain this developmental state. Then, as growth conditions improve, activation of the LIN-12 Notch receptor cooperates with the insulin-like signalling pathway to signal recovery from the dauer stage.}, author = {Ouellet, J. and Li, S. and Roy, R.}, citeulike-article-id = {3337803}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/18599512}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=18599512}, citeulike-linkout-2 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00031997}, journal = {Development}, keywords = {b04122, c47g22, c\_elegans, caenorhabditis\_elegans, celegans, daf-16, daf-2, daf-7, elegans, f02a96, glp-1, ins-18, k08b41, lag-1, lag-2, lin-12, nematode, other, r1078, r13h81, t28b82, unc-130, wormbase, y55d5a5, y73c8b4}, posted-at = {2008-09-25 18:20:11}, priority = {3}, title = {Notch signalling is required for both dauer maintenance and recovery in C. elegans.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18599512}, year = {2008} }

TY - JOUR ID - citeulike:3337803 L3 - citeulike-article-id:3337803 N2 - The Notch signalling pathway is conserved among higher metazoans and is used repeatedly throughout development to specify distinct cell fates among populations of equipotent cells. Mounting evidence suggests that Notch signalling may also be crucial in neuronal function in postmitotic, differentiated neurons. Here, we demonstrate a novel role for the canonical Notch signalling pathway in postmitotic neurons during a specialised ''diapause-like'' post-embryonic developmental stage in C. elegans called dauer. Our data suggest that cell signalling downstream of the developmental decision to enter dauer leads to the activation of Notch-responding genes in postmitotic neurons. Consistent with this, we demonstrate that glp-1, one of the two C. elegans Notch receptors, and its ligand lag-2 are expressed in neurons during the dauer stage, and both genes are required to maintain this stage in a daf-7/TGFbeta dauer constitutive background. Our genetic data also suggest that a second Notch receptor, lin-12, functions upstream of, or in parallel with, insulin-like signalling components in response to replete growth conditions to promote dauer recovery. Based on our findings, cues associated with the onset of dauer ultimately trigger a glp-1-dependent Notch signalling cascade in neurons to maintain this developmental state. Then, as growth conditions improve, activation of the LIN-12 Notch receptor cooperates with the insulin-like signalling pathway to signal recovery from the dauer stage. JF - Development TI - Notch signalling is required for both dauer maintenance and recovery in C. elegans. KW - b04122 KW - c47g22 KW - c_elegans KW - caenorhabditis_elegans KW - celegans KW - daf-16 KW - daf-2 KW - daf-7 KW - elegans KW - f02a96 KW - glp-1 KW - ins-18 KW - k08b41 KW - lag-1 KW - lag-2 KW - lin-12 KW - nematode KW - other KW - r1078 KW - r13h81 KW - t28b82 KW - unc-130 KW - wormbase KW - y55d5a5 KW - y73c8b4 AU - Ouellet, J AU - Li, S AU - Roy, R PY - 2008/// UR - http://view.ncbi.nlm.nih.gov/pubmed/18599512 ER -