Unfolded protein response genes regulated by CED-1 are required for Caenorhabditis elegans innate immunity. Export

@article{citeulike:3337810, abstract = {The endoplasmic reticulum stress response, also known as the unfolded protein response (UPR), has been implicated in the normal physiology of immune defense and in several disorders, including diabetes, cancer, and neurodegenerative disease. Here, we show that the apoptotic receptor CED-1 and a network of PQN/ABU proteins involved in a noncanonical UPR response are required for proper defense to pathogen infection in Caenorhabditis elegans. A full-genome microarray analysis indicates that CED-1 functions to activate the expression of pqn/abu genes. We also show that ced-1 and pqn/abu genes are required for the survival of C. elegans exposed to live Salmonella enterica, and that overexpression of pqn/abu genes confers protection against pathogen-mediated killing. The results indicate that unfolded protein response genes, regulated in a CED-1-dependent manner, are involved in the C. elegans immune response to live bacteria.}, author = {Haskins, K. A. and Russell, J. F. and Gaddis, N. and Dressman, H. K. and Aballay, A.}, citeulike-article-id = {3337810}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/18606143}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=18606143}, citeulike-linkout-2 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00032003}, journal = {Dev Cell}, keywords = {article, c\_elegans, caenorhabditis\_elegans, ced-1, celegans, elegans, nematode, wormbase, y47h9c4}, pages = {87--97}, posted-at = {2008-09-25 18:22:08}, priority = {3}, title = {Unfolded protein response genes regulated by CED-1 are required for Caenorhabditis elegans innate immunity.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18606143}, volume = {15}, year = {2008} }

TY - JOUR ID - citeulike:3337810 L3 - citeulike-article-id:3337810 N2 - The endoplasmic reticulum stress response, also known as the unfolded protein response (UPR), has been implicated in the normal physiology of immune defense and in several disorders, including diabetes, cancer, and neurodegenerative disease. Here, we show that the apoptotic receptor CED-1 and a network of PQN/ABU proteins involved in a noncanonical UPR response are required for proper defense to pathogen infection in Caenorhabditis elegans. A full-genome microarray analysis indicates that CED-1 functions to activate the expression of pqn/abu genes. We also show that ced-1 and pqn/abu genes are required for the survival of C. elegans exposed to live Salmonella enterica, and that overexpression of pqn/abu genes confers protection against pathogen-mediated killing. The results indicate that unfolded protein response genes, regulated in a CED-1-dependent manner, are involved in the C. elegans immune response to live bacteria. JF - Dev Cell EP - 97 TI - Unfolded protein response genes regulated by CED-1 are required for Caenorhabditis elegans innate immunity. VL - 15 SP - 87 KW - article KW - c_elegans KW - caenorhabditis_elegans KW - ced-1 KW - celegans KW - elegans KW - nematode KW - wormbase KW - y47h9c4 AU - Haskins, KA AU - Russell, JF AU - Gaddis, N AU - Dressman, HK AU - Aballay, A PY - 2008/// UR - http://view.ncbi.nlm.nih.gov/pubmed/18606143 ER -