Localization and expression analysis of a novel conserved brain expressed transcript, Brx/BRX, lying within the Xic/XIC candidate region. Export

@article{citeulike:3337852, abstract = {The X inactivation center candidate region (Xic/XIC in mouse and human) is poorly characterized for the presence of transcription units. Only two conserved genes have been isolated to date, Xist/XIST and Cdx4/CDX4. The other known gene lying within this region, Tsx, has been identified so far only in rodents by analyzing the complete genomic sequence of a 94-kb region distal to Xist. Here, we report the characterization of an additional gene lying within this 94-kb sequenced region. Brx, for Brain X-linked gene, is a rare transcript preferentially expressed in the brain. It is normally X-inactivated in the mouse. Localisation of BRX, its human homolog has shown the gene to be located within the orthologous but inverted human CDX4-XIST segment. These results suggest that the gene order of the region encompassing the Cdx4-Xist interval in the mouse is similar in human. Comparison of the Xist-Brx and Brx-Cdx4 regions in mouse and human indicates that these intervals are three times longer in human than in mouse. BRX is a new potential candidate for one of the X-linked mental retardation syndromes mapped within the pericentromeric region of the human X Chromosome (Chr).}, author = {Simmler, M. C. and Heard, E. and Rougeulle, C. and Cruaud, C. and Weissenbach, J. and Avner, P.}, citeulike-article-id = {3337852}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/9321471}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=9321471}, citeulike-linkout-2 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00032045}, journal = {Mamm Genome}, keywords = {article, c\_elegans, caenorhabditis\_elegans, celegans, elegans, nematode, wormbase}, pages = {760--766}, posted-at = {2008-09-25 18:32:02}, priority = {3}, title = {Localization and expression analysis of a novel conserved brain expressed transcript, Brx/BRX, lying within the Xic/XIC candidate region.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/9321471}, volume = {8}, year = {1997} }

TY - JOUR ID - citeulike:3337852 L3 - citeulike-article-id:3337852 N2 - The X inactivation center candidate region (Xic/XIC in mouse and human) is poorly characterized for the presence of transcription units. Only two conserved genes have been isolated to date, Xist/XIST and Cdx4/CDX4. The other known gene lying within this region, Tsx, has been identified so far only in rodents by analyzing the complete genomic sequence of a 94-kb region distal to Xist. Here, we report the characterization of an additional gene lying within this 94-kb sequenced region. Brx, for Brain X-linked gene, is a rare transcript preferentially expressed in the brain. It is normally X-inactivated in the mouse. Localisation of BRX, its human homolog has shown the gene to be located within the orthologous but inverted human CDX4-XIST segment. These results suggest that the gene order of the region encompassing the Cdx4-Xist interval in the mouse is similar in human. Comparison of the Xist-Brx and Brx-Cdx4 regions in mouse and human indicates that these intervals are three times longer in human than in mouse. BRX is a new potential candidate for one of the X-linked mental retardation syndromes mapped within the pericentromeric region of the human X Chromosome (Chr). JF - Mamm Genome EP - 766 TI - Localization and expression analysis of a novel conserved brain expressed transcript, Brx/BRX, lying within the Xic/XIC candidate region. VL - 8 SP - 760 KW - article KW - c_elegans KW - caenorhabditis_elegans KW - celegans KW - elegans KW - nematode KW - wormbase AU - Simmler, MC AU - Heard, E AU - Rougeulle, C AU - Cruaud, C AU - Weissenbach, J AU - Avner, P PY - 1997/// UR - http://view.ncbi.nlm.nih.gov/pubmed/9321471 ER -