Epigenetic events in mammalian germ-cell development: reprogramming and beyond Export

@article{citeulike:2251009, abstract = {The epigenetic profile of germ cells, which is defined by modifications of DNA and chromatin, changes dynamically during their development. Many of the changes are associated with the acquisition of the capacity to support post-fertilization development. Our knowledge of this aspect has greatly increased- for example, insights into how the re-establishment of parental imprints is regulated. In addition, an emerging theme from recent studies is that epigenetic modifiers have key roles in germ-cell development itself--for example, epigenetics contributes to the gene-expression programme that is required for germ-cell development, regulation of meiosis and genomic integrity. Understanding epigenetic regulation in germ cells has implications for reproductive engineering technologies and human health.}, author = {Sasaki, Hiroyuki and Matsui, Yasuhisa}, citeulike-article-id = {2251009}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrg2295}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrg2295}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18197165}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18197165}, doi = {10.1038/nrg2295}, journal = {Nat Rev Genet}, keywords = {cancer-crosstalk, epigenetics, germ-cells, imprinting, reprogramming}, month = {February}, number = {2}, pages = {129--140}, posted-at = {2009-01-30 23:21:01}, priority = {2}, publisher = {Nature Publishing Group}, title = {Epigenetic events in mammalian germ-cell development: reprogramming and beyond}, url = {http://dx.doi.org/10.1038/nrg2295}, volume = {9}, year = {2008} }

TY - JOUR ID - citeulike:2251009 L3 - citeulike-article-id:2251009 N2 - The epigenetic profile of germ cells, which is defined by modifications of DNA and chromatin, changes dynamically during their development. Many of the changes are associated with the acquisition of the capacity to support post-fertilization development. Our knowledge of this aspect has greatly increased- for example, insights into how the re-establishment of parental imprints is regulated. In addition, an emerging theme from recent studies is that epigenetic modifiers have key roles in germ-cell development itself--for example, epigenetics contributes to the gene-expression programme that is required for germ-cell development, regulation of meiosis and genomic integrity. Understanding epigenetic regulation in germ cells has implications for reproductive engineering technologies and human health. IS - 2 JF - Nat Rev Genet EP - 140 TI - Epigenetic events in mammalian germ-cell development: reprogramming and beyond PB - Nature Publishing Group VL - 9 SP - 129 KW - cancer-crosstalk KW - epigenetics KW - germ-cells KW - imprinting KW - reprogramming AU - Sasaki, Hiroyuki AU - Matsui, Yasuhisa PY - 2008/02// UR - http://dx.doi.org/10.1038/nrg2295 ER -