Metabolomics: Biochemistry's new look Export

@article{citeulike:3365423, author = {Blow, Nathan}, citeulike-article-id = {3365423}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/455697a}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/455697a}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18833281}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18833281}, comment = {Excerpt: Metabolomics — the comprehensive study of metabolic reactions — is gaining ground alongside its older siblings genomics and proteomics. "Unlike some of the other 'omics' that we have seen, metabolomics is going to produce a lot of useful information right from the start," says Gary Siuzdak, professor of molecular biology at the Scripps Research Institute in La Jolla, California. He is one of a growing number of biologists using advanced technology to explore biochemical questions on a scale that would have seemed impossible a decade ago. "The metabolome is the best indicator of an organism's phenotype," says David Wishart at the University of Alberta in Edmonton, Canada. Wishart was one of the instigators of the Human Metabolome Project, a US\$7.5-million effort funded by Genome Canada to systematically characterize the metabolites of the human body. He gives the example of a person holding their breath for five minutes. Although genomic or proteomic analysis would not provide any evidence of stress during this short period — even as the person turns blue — metabolite profiles would show dramatic changes within the body.}, day = {2}, doi = {10.1038/455697a}, journal = {Nature}, keywords = {biochemistry, cancer-crosstalk, metabolomics}, month = {October}, number = {7213}, pages = {697--700}, posted-at = {2008-10-03 01:09:52}, priority = {2}, publisher = {Nature Publishing Group}, title = {Metabolomics: Biochemistry's new look}, url = {http://dx.doi.org/10.1038/455697a}, volume = {455}, year = {2008} }

TY - JOUR ID - citeulike:3365423 L3 - citeulike-article-id:3365423 IS - 7213 JF - Nature EP - 700 TI - Metabolomics: Biochemistry's new look PB - Nature Publishing Group VL - 455 SP - 697 KW - biochemistry KW - cancer-crosstalk KW - metabolomics N1 - Excerpt: Metabolomics — the comprehensive study of metabolic reactions — is gaining ground alongside its older siblings genomics and proteomics. "Unlike some of the other 'omics' that we have seen, metabolomics is going to produce a lot of useful information right from the start," says Gary Siuzdak, professor of molecular biology at the Scripps Research Institute in La Jolla, California. He is one of a growing number of biologists using advanced technology to explore biochemical questions on a scale that would have seemed impossible a decade ago. "The metabolome is the best indicator of an organism's phenotype," says David Wishart at the University of Alberta in Edmonton, Canada. Wishart was one of the instigators of the Human Metabolome Project, a US$7.5-million effort funded by Genome Canada to systematically characterize the metabolites of the human body. He gives the example of a person holding their breath for five minutes. Although genomic or proteomic analysis would not provide any evidence of stress during this short period — even as the person turns blue — metabolite profiles would show dramatic changes within the body. AU - Blow, Nathan PY - 2008/10/02/ UR - http://dx.doi.org/10.1038/455697a ER -