Small RNA: A Large Contributor to Carcinogenesis? Export

@article{citeulike:4381333, abstract = {Abstract Introduction\ \ Homeostasis in normal tissue includes balancing cell proliferation and apoptosis (programmed cell death). Mutations in proto-oncogenes or tumor suppressor genes may lead to disruption of normal cellular function, uncontrolled cell proliferation, and subsequent carcinogenesis. Discussion\ \ Micro-RNAs (miRNAs) are short (19–24 nucleotide) noncoding RNA sequences that inhibit protein translation and can cause the degradation of subsequent messenger RNA, thus playing an important role in the regulation of gene expression. Aberrant expression of miRNAs has been shown to inhibit tumor suppressor genes or inappropriately activate oncogenes initiating the cancer process. Unique miRNA expression profiles have been found in different cancer types at different stages, suggesting a possible diagnostic application. This review summarizes the current evidence supporting a link between aberrant miRNA expression and carcinogenesis and its possible role in improving diagnosis and treatment of cancers, particularly of gastrointestinal origin.}, author = {Bhatti, Imran and Lee, Andrew and Lund, Jonathan and Larvin, Michael}, citeulike-article-id = {4381333}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s11605-009-0887-6}, citeulike-linkout-1 = {http://www.springerlink.com/content/w49716883r476747}, day = {1}, doi = {10.1007/s11605-009-0887-6}, journal = {Journal of Gastrointestinal Surgery}, keywords = {mirna, review}, month = {July}, number = {7}, pages = {1379--1388}, posted-at = {2009-11-08 22:14:40}, priority = {2}, title = {Small RNA: A Large Contributor to Carcinogenesis?}, url = {http://dx.doi.org/10.1007/s11605-009-0887-6}, volume = {13}, year = {2009} }

TY - JOUR ID - citeulike:4381333 L3 - citeulike-article-id:4381333 N2 - Abstract Introduction  Homeostasis in normal tissue includes balancing cell proliferation and apoptosis (programmed cell death). Mutations in proto-oncogenes or tumor suppressor genes may lead to disruption of normal cellular function, uncontrolled cell proliferation, and subsequent carcinogenesis. Discussion  Micro-RNAs (miRNAs) are short (19–24 nucleotide) noncoding RNA sequences that inhibit protein translation and can cause the degradation of subsequent messenger RNA, thus playing an important role in the regulation of gene expression. Aberrant expression of miRNAs has been shown to inhibit tumor suppressor genes or inappropriately activate oncogenes initiating the cancer process. Unique miRNA expression profiles have been found in different cancer types at different stages, suggesting a possible diagnostic application. This review summarizes the current evidence supporting a link between aberrant miRNA expression and carcinogenesis and its possible role in improving diagnosis and treatment of cancers, particularly of gastrointestinal origin. IS - 7 JF - Journal of Gastrointestinal Surgery EP - 1388 TI - Small RNA: A Large Contributor to Carcinogenesis? VL - 13 SP - 1379 KW - mirna KW - review AU - Bhatti, Imran AU - Lee, Andrew AU - Lund, Jonathan AU - Larvin, Michael PY - 2009/07/01/ UR - http://dx.doi.org/10.1007/s11605-009-0887-6 ER -